Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. [PDF]
Mol Pharmacol, 2023 AbstractAtypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that regulates extracellular chemokine levels through scavenging. The scavenging action mediates the availability of the chemokine CXCL12 for the G protein-coupled receptor (GPCR) CXCR4 and requires phosphorylation of the ACKR3 C-terminus by GPCR kinases (GRKs).
Schafer CT +3 more
europepmc +7 more sources
Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. [PDF]
Front Immunol, 2019 Chemokine receptor CXCR4, its ligand stromal cell-derived factor-1 (CXCL12) and the decoy receptor atypical chemokine receptor 3 (ACKR3, also named CXCR7), are involved in the guidance of migrating cells in different anatomical districts.
Tobia C +8 more
europepmc +2 more sources
Conformational dynamics underlying atypical chemokine receptor 3 activation. [PDF]
Proc Natl Acad Sci U S A, 2023 AbstractAtypical Chemokine Receptor 3 (ACKR3) is a G protein-coupled receptor that does not signal through G proteins. It is known as a chemokine scavenger involved in various pathologies, making it an appealing yet intriguing therapeutic target. Indeed, the structural properties that govern ACKR3 functional selectivity and the overall conformational ...
Otun O +13 more
europepmc +4 more sources
Prospects for targeting ACKR1 in cancer and other diseases
Frontiers in Immunology, 2023 The chemokine network is comprised of a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs).
Kyler S. Crawford, Brian F. Volkman
doaj +1 more source
The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis. [PDF]
J Immunol, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Hansell CAH +12 more
europepmc +3 more sources
Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties
Frontiers in Molecular Biosciences, 2022 ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration.
Alessandro Vacchini +16 more
doaj +1 more source
Atypical Chemokine Receptors in Renal Inflammation [PDF]
Nephron Experimental Nephrology, 2010 Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic angiogenesis. In
Segerer, S, Jedlicka, J, Wüthrich, R P
openaire +3 more sources
Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD [PDF]
Current Medicinal Chemistry, 2021 Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells.
Francesco Nucera +10 more
openaire +5 more sources
ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production
Frontiers in Immunology, 2023 Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
Paola Antonello +10 more
doaj +1 more source
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3 [PDF]
Molecular Pharmacology, 2019 G protein-coupled receptors (GPCRs) are regulated by complex molecular mechanisms, both in physiologic and pathologic conditions, and their signaling can be intricate. Many factors influence their signaling behavior, including the type of ligand that activates the GPCR, the presence of interacting partners, the kinetics involved, or their location. The
Heuninck, Joyce +11 more
openaire +5 more sources