Results 101 to 110 of about 1,031,034 (270)

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions

Frontiers in Physiology
Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias.
Meye Bloothooft, Bente Verbruggen, Fitzwilliam Seibertz, Fitzwilliam Seibertz, Fitzwilliam Seibertz, Fitzwilliam Seibertz, Marcel A. G. van der Heyden, Niels Voigt, Niels Voigt, Niels Voigt, Teun P. de Boer   +10 more
doaj   +1 more source

Automated planar patch clamp: Multiple applications for miniaturized devices

The FASEB Journal, 2009
The Port‐a‐Patch is a miniaturized patch clamp rig which uses a planar borosilicate glass chip for performing electrophysiological recordings. Suction applied from the underside of the chip is used to attract a single cell to the recording site without the need for optical visualization ...
Claudia Haarmann, Alison Haythornthwaite, Andrea Brueggemann, Sonja Stoelzle, Cecilia Farre, Michael George, Niels Fertig   +6 more
openaire   +1 more source

Robotic automation of in vivo two photon targeted whole-cell patch clamp electrophysiology [PDF]

, 2017
Whole-cell patch-clamp electrophysiological recording is a powerful technique for studying cellular function. While in vivo patch-clamp recording has recently benefited from automation, it is normally performed “blind,” meaning that throughput for ...
Agabi, OE, Copeland, Caroline, Morris, Alexander R, Schultz, SR, Simon R. Schultz, Caroline S. Copeland, Annecchino, Luca, Chadderton, Paul, Schultz, Simon, Agabi, Oshioroyena, Morris, AR, Chadderton, P, Luca A. Annecchino, Paul Chadderton, Annecchino, Luca A, Annecchino, LA, Agabi, Oshiorenoya E., Oshiorenoya E. Agabi, Copeland, Caroline S., Morris, Alexander, Alexander R. Morris, Schultz, Simon R, Copeland, CS   +22 more
core   +1 more source

Multiscale Interfacial Engineering Enables Robust Reconstituted Wood

Advanced Science, EarlyView.
Conventional adhesives used in wood composites create heterogeneous interfaces that cause stress concentration under humid or aqueous conditions, thereby compromising long‐term stability. A synergistic strategy integrating interfacial reconstruction and water‐induced regeneration transforms heterogeneous interfaces into homogeneous ones with ...
Huizheng Wu, Yi Kong, Liangxian Liu, Yuyan Jiang, Jiahuan He, Haiyu Li, Ming Wei, Dexiu Min, Jian Li, Yanjun Xie, Chi Zhang, Shaoliang Xiao   +11 more
wiley   +1 more source

Multi-neuron intracellular recording in vivo via interacting autopatching robots

eLife, 2018
The activities of groups of neurons in a circuit or brain region are important for neuronal computations that contribute to behaviors and disease states.
Suhasa B Kodandaramaiah, Francisco J Flores, Gregory L Holst, Annabelle C Singer, Xue Han, Emery N Brown, Edward S Boyden, Craig R Forest   +7 more
doaj   +1 more source

Culturing and electrophysiology of cells on NRCC patch-clamp chips

, 2012
Due to its exquisite sensitivity and the ability to monitor and control individual cells at the level of ion channels, patch-clamping is the gold standard of electrophysiology applied to disease models and pharmaceutical screens alike 1.
Py, Christophe, Monette, Robert, Martina, Marzia, Luk, Collin, Mealing, Geoff, Comas, Tanya, Denhoff, Mike W., Syed, Naweed I.   +7 more
core   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Automated in vivo patch-clamp evaluation of extracellular multielectrode array spike recording capability

, 2019
© 2018 American Physiological Society. All rights reserved. Much innovation is currently aimed at improving the number, density, and geometry of electrodes on extracellular multielectrode arrays for in vivo recording of neural activity in the mammalian ...
Tegmark, Max, Lamantia, Charlie, Seoane, Luís F, Boyden, Edward S, Kinney, Justin P, Scholvin, Jorg, Chronopoulos, Chris, Bernstein, Jacob G, Moore-Kochlacs, Caroline, Kodandaramaiah, Suhasa B, Allen, Brian D   +10 more
core   +1 more source

Characterizing Biopolymer Electrolytes in Zinc–Air Batteries: Challenges, Best Practices, and a Robust Workflow Guiding Future Research Paths

Advanced Energy Materials, EarlyView.
Bio‐based gel polymer electrolytes promise sustainable, mechanically adaptable zinc–air batteries, yet their progress is constrained by inconsistent characterization. This review critically links formulation, structure, interfaces, and cell performance, identifies methodological gaps under alkaline operating conditions, and proposes application ...
Matteo Milanesi, Hiba Ali, Barbara Belza, Mattia F. Palermo, Claudio Gerbaldi, Giuseppe Antonio Elia, Nagore Ortiz‐Vitoriano   +6 more
wiley   +1 more source