Results 101 to 110 of about 15,553 (191)

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

Microbiology Spectrum
Cefiderocol, a siderophore-cephalosporine conjugate antibiotic, shows promise as a therapeutic option for carbapenem-resistant (CR) Acinetobacter infections. While resistance has already been reported in A. baumannii, combination therapies with avibactam
Olivia Wong, Vyanka Mezcord, Christina Lopez, German Matias Traglia, Fernando Pasteran, Marisel R. Tuttobene, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, María Soledad Ramirez   +9 more
doaj   +1 more source

Point prevalence surveys of antimicrobial use among eight neonatal intensive care units in India: 2016 [PDF]

, 2018
BACKGROUND: Information about antimicrobial use is scarce and poorly understood among neonatal intensive care units (NICUs) in India. In this study, we describe antimicrobial use in eight NICUs using four point prevalence surveys (PPSs). METHODS: As part
Akula, Akhila, Alvarez-Uria, Gerardo, Chikkappa, Ashok K., Dharmapalan, Dhanya, Gandra, Sumanth, Hsia, Yingfen, Hsia, Yingfen, Jinka, Dasaratha R., Kandraju, Hemasree, Kanithi, Ravishankar, Laxminarayan, Ramanan, Murki, Srinivas, Sharland, Mike, Sharma, Anita, Singh, Sanjeev K., Subramanian, Sreeram, Tunga, Onkaraiah, Vasudevan , Anil Kumar   +17 more
core   +2 more sources

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

mBio, 2017
The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that inactivate “last-line” antibiotics such as imipenem, represents a major challenge to contemporary antibiotic therapies.
Melissa D. Barnes, Marisa L. Winkler, Magdalena A. Taracila, Malcolm G. Page, Eric Desarbre, Barry N. Kreiswirth, Ryan K. Shields, Minh-Hong Nguyen, Cornelius Clancy, Brad Spellberg, Krisztina M. Papp-Wallace, Robert A. Bonomo   +11 more
doaj   +1 more source

Shifting Gears: The Future of Polymyxin Antibiotics

Antibiotics, 2019
The manuscripts contained in this special edition of Antibiotics represent a current review of the polymyxins as well as highlights from the 3rd International Polymyxin Conference, which was held in Madrid, Spain, 25 to 26 April 2018.
Justin R. Lenhard, Zackery P. Bulman, Brian T. Tsuji, Keith S. Kaye   +3 more
doaj   +1 more source

Clinical Evolution of New Delhi Metallo-β-Lactamase (NDM) optimizes resistance under Zn(II) Deprivation [PDF]

, 2018
Carbapenem-resistant Enterobacteriaceae (CRE) are rapidly spreading and taking a staggering toll on all health care systems, largely due to the dissemination of genes coding for potent carbapenemases.
Bahr, Guillermo, Bethel, Christopher R., Bonomo, Robert A., Gonzalez, Lisandro Javier, Vila, Alejandro Jose, Vitor Horen, Luisina   +5 more
core   +1 more source

Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Update on Therapeutic Options

Frontiers in Microbiology, 2019
Carbapenems are considered as last-resort antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in clinical practice, the emergence of carbapenem-resistant pathogens now ...
Chau-Chyun Sheu, Chau-Chyun Sheu, Ya-Ting Chang, Ya-Ting Chang, Shang-Yi Lin, Shang-Yi Lin, Yen-Hsu Chen, Yen-Hsu Chen, Yen-Hsu Chen, Po-Ren Hsueh, Po-Ren Hsueh   +10 more
doaj   +1 more source

Treatment Options for urinary tract infections caused by extended-spectrum B-lactamase-producing Escherichia coli and Klebsiella pneumoniae [PDF]

, 2015
Increased utilization of antibiotics has contributed to greater resistance among pathogenic bacteria. The prevalence of such organisms has created challenges for practitioners treating bacterial infections.
Resman-Targoff, Beth, Salvatore, Dominick   +1 more
core  

Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem [PDF]

, 2016
BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes).
Benvenuti, Manuela, Docquier, Jean-Denis, Luca, Filomena De, Mangani, Stefano, Nordmann, Patrice, Poirel, Laurent, Pozzi, Cecilia, Rossolini, Gian Maria   +7 more
core   +1 more source

Avibactam–Cyclodextrin Inclusion Complexes: Computational and Thermodynamic Insights for Drug Delivery, Detection, and Environmental Scavenging

Molecules
The escalating crisis of multidrug resistance, together with the persistence of antibiotic residues in clinical and environmental matrices, demands integrated strategies that couple sensitive detection, efficient decontamination, and controlled delivery.
Jackson J. Alcázar, Paola R. Campodónico, René López   +2 more
doaj   +1 more source

Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease

IJTLD Open
BACKGROUND: Guideline-based therapy (GBT) of Mycobacterium abscessus (MAB) lung disease (LD) achieves a sputum culture conversion rate in ∼35% of patients. The β-lactam antibiotics, imipenem and cefoxitin, are the cornerstone of GBT.
B.E. Ferro, S. Srivastava, T. Gumbo
doaj   +1 more source