Results 141 to 150 of about 938,041 (332)

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration

eLife, 2018
The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury.
Kyung Won Kim, Ngang Heok Tang, Christopher A Piggott, Matthew G Andrusiak, Seungmee Park, Ming Zhu, Naina Kurup, Salvatore J Cherra III, Zilu Wu, Andrew D Chisholm, Yishi Jin   +10 more
doaj   +1 more source

Versatile DNA‐Functionalized Biohybrid Hydrogel Platforms for Electrothermally Activated On‐Demand Payload Release

Advanced Science, EarlyView.
A DNA‐functionalized biohybrid hydrogel is developed by integrating Cu‐mediated nucleic acid microflowers into a thermoresponsive matrix, enabling electrothermally triggered, on‐demand payload release. The platform offers spatiotemporally controllable therapeutic delivery with promising applications in precision oncology, neural regulation, and chronic
Mengqiu Sun, Zhenshuai Tang, Jia Zhang, Rui Song, Wei Luo, Juan Huang, Jincheng Zeng, Zhen He, Hao Zhang   +8 more
wiley   +1 more source

Axon regeneration: an issue of translation

Comptes Rendus. Biologies
In the mammalian central nervous system (CNS), adult neurons fail to regenerate spontaneously upon axon injury, which leads to a permanent and irreversible loss of neuronal functions. For more than 15 years, much effort was invested to unlock axon regrowth programs based on extensive transcriptomic characterization.
Julia Schaeffer, Stephane Belin
openaire   +4 more sources

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration

, 2013
SummaryReactivation of a silent transcriptional program is a critical step in successful axon regeneration following injury. Yet how such a program is unlocked after injury remains largely unexplored.
Naegle, Kristen M., Cavalli, Valeria, Cho, Yongcheol, Sloutsky, Roman   +3 more
core   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

Advanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang, Jingyu Tian, Zhe Xu, Cuiling Zhang, Jingen Wu, Ming Liu, Zhilu Ye, Xiaohui Zhang   +7 more
wiley   +1 more source

DLK orchestrates a modular transcriptional response to axon injury with separate roles for Fos and Jun.

PLoS Genetics
Axon injury initiates transcriptional reprogramming that in competent cells leads to regeneration. In vertebrate neurons, DLK acts upstream of Jun, STAT and Atf3, core transcription factors that mediate regeneration.
Gibarni Mahata, Li Chen, Gregory O Kothe, Melissa M Rolls   +3 more
doaj   +1 more source

Spinal Cord Repair: Strategies to Promote Axon Regeneration

Neurobiology of Disease, 2001
Neurons in the central nervous system have a remarkable capacity to regenerate their transected axons when provided with an appropriate growth environment.
Lisa McKerracher
doaj   +1 more source

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

Scientific Reports, 2017
Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in axon regeneration. Unfortunately, currently established treatments, such as direct drug administration, do not effectively treat SCI due to rapid drug ...
L. Nguyen, Mingyong Gao, Junquan Lin, Wutian Wu, Jun Wang, S. Y. Chew   +5 more
semanticscholar   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Genetic mouse models for studying inhibitors of spinal axon regeneration

, 2006
The laboratory mouse has emerged as a primary model organism for studying axon regeneration after experimental spinal cord injury, owing to its genetic amenability.
Xie, Fang, Lee, Jae K, Zheng, Binhai
core   +1 more source