Results 151 to 160 of about 938,041 (332)
Frontiers in Cellular Neuroscience, 2017 Limited axon regeneration in the injured adult mammalian central nervous system (CNS) usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory molecules at the injury site and the intrinsically low capacity of adult ...
Vinicius T. Ribas, Marcos R. Costa
doaj +1 more source
Advanced Science, EarlyView.A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo +5 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Functional impairment and poor recovery following central nervous system injury is due to the failure of injured axons to regenerate and rebuild functional connections.
Y. M. Oh +5 more
semanticscholar +1 more source
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS
Journal of Neuroscience, 2017 Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here,
Akintomide Apara +16 more
semanticscholar +1 more source
The Genetics of Functional Axon Regeneration Using C. Elegans
, 2019 How do organisms attain the capacity to regenerate a structure, entire body, or not to regenerate? These are fundamental questions in biology for understanding how replicative systems are evolved to renew, age, and/or die.
Belew, Micah Y.
core +1 more source
Receptor tyrosine kinases: molecular switches regulating CNS axon regeneration [PDF]
, 2012 The poor or lack of injured adult central nervous system (CNS) axon regeneration results in devastating consequences and poor functional recovery.
Ahmed, Zubair; id_orcid
core +1 more source
Advanced Science, EarlyView.In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu +13 more
wiley +1 more source
Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond
Advanced Science, EarlyView.Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu +5 more
wiley +1 more source
Linking axon transport to regeneration usinglaser axotomy
, 2018 Spinal cord injury has devastating consequences because adult central nervous system (CNS) neurons do not regenerate their axons after injury. Two key reasons for axon regeneration failure are extrinsic inhibitory factors and a low intrinsic capacity for
Richard Eva +3 more
core +1 more source