Results 11 to 20 of about 769,118 (313)
eLife, 2018 The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury.
Kyung Won Kim +10 more
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Frontiers in Immunology, 2022 Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit due to the massive loss of retinal ganglion cells (RGCs) and their ...
N. Au, C. H. Ma
semanticscholar +1 more source
EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor
Cells, 2021 Axon regeneration after injury is a conserved biological process that involves a large number of molecular pathways, including rapid calcium influx at injury sites, retrograde injury signaling, epigenetic transition, transcriptional reprogramming ...
Gilberto Gonzalez, Lizhen Chen
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Advancement of science, 2021 Current treatment approaches toward spinal cord injuries (SCI) have mainly focused on overcoming the inhibitory microenvironment that surrounds lesion sites.
Na Zhang +10 more
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Journal of Neuroscience, 2021 Axon regenerative failure in the mature CNS contributes to functional deficits following many traumatic injuries, ischemic injuries, and neurodegenerative diseases.
Sheri L. Peterson +9 more
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Frontiers in Molecular Neuroscience, 2022 Injured sensory neurons activate a transcriptional program necessary for robust axon regeneration and eventual target reinnervation. Understanding the transcriptional regulators that govern this axon regenerative response may guide therapeutic strategies
Oshri Avraham +9 more
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Axon Regeneration: A Subcellular Extension in Multiple Dimensions.
Cold Spring Harbor Perspectives in Biology, 2021 Axons are a unique cellular structure that allows for the communication between neurons. Axon damage compromises neuronal communications and often leads to functional deficits.
Carla C. Winter, Zhigang He, A. Jacobi
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Cells, 2021 CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence of axon growth inhibitory molecules. One such potent inhibitor of CNS axon regeneration is Reticulon (RTN)
Sharif Alhajlah +2 more
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PDK1 is a negative regulator of axon regeneration
Molecular Brain, 2021 Axon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various conditions.
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
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A novel neutrophil subset promotes CNS neuron survival and axon regeneration
Nature Immunology, 2020 Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic brain or spinal cord injury, glaucoma and ischemia–reperfusion injury of the eye.
A. Sas +7 more
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