Results 11 to 20 of about 50,535 (307)

Axonal Regeneration by Glycosaminoglycan [PDF]

Frontiers in Cell and Developmental Biology, 2021
Like other biomolecules including nucleic acid and protein, glycan plays pivotal roles in various cellular processes. For instance, it modulates protein folding and stability, organizes extracellular matrix and tissue elasticity, and regulates membrane trafficking.
Kazuma Sakamoto, Kazuma Sakamoto, Tomoya Ozaki, Kenji Kadomatsu, Kenji Kadomatsu   +4 more
openaire   +3 more sources

Chromatin accessibility regulates axon regeneration. [PDF]

Neural Regen Res
Samad I, Hilton BJ.
europepmc   +5 more sources

A Commentary on "Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway". [PDF]

Neurospine
Xue W, Dai A, Liu Q.
europepmc   +3 more sources

EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor

Cells, 2021
Axon regeneration after injury is a conserved biological process that involves a large number of molecular pathways, including rapid calcium influx at injury sites, retrograde injury signaling, epigenetic transition, transcriptional reprogramming ...
Gilberto Gonzalez, Lizhen Chen
doaj   +1 more source

Analysis of neuronal injury transcriptional response identifies CTCF and YY1 as co-operating factors regulating axon regeneration

Frontiers in Molecular Neuroscience, 2022
Injured sensory neurons activate a transcriptional program necessary for robust axon regeneration and eventual target reinnervation. Understanding the transcriptional regulators that govern this axon regenerative response may guide therapeutic strategies
Oshri Avraham, Jimmy Le, Kathleen Leahy, Tiandao Li, Tiandao Li, Guoyan Zhao, Guoyan Zhao, Valeria Cavalli, Valeria Cavalli, Valeria Cavalli   +9 more
doaj   +1 more source

Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

Cell Reports, 2020
Summary: In addition to altered gene expression, pathological cytoskeletal dynamics in the axon are another key intrinsic barrier for axon regeneration in the central nervous system (CNS). Here, we show that knocking out myosin IIA and IIB (myosin IIA/B)
Xue-Wei Wang, Shu-Guang Yang, Chi Zhang, Ming-Wen Hu, Jiang Qian, Jin-Jin Ma, Yingchi Zhang, Bin-Bin Yang, Yi-Lan Weng, Guo-Li Ming, Anish R. Kosanam, Saijilafu, Feng-Quan Zhou   +12 more
doaj   +1 more source

Overexpression of Reticulon 3 Enhances CNS Axon Regeneration and Functional Recovery after Traumatic Injury

Cells, 2021
CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence of axon growth inhibitory molecules. One such potent inhibitor of CNS axon regeneration is Reticulon (RTN)
Sharif Alhajlah, Adam M Thompson, Zubair Ahmed   +2 more
doaj   +1 more source

Intra-axonal mechanisms driving axon regeneration

Brain Research, 2020
Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P, Smith, Pabitra K, Sahoo, Amar N, Kar, Jeffery L, Twiss   +3 more
openaire   +3 more sources

PDK1 is a negative regulator of axon regeneration

Molecular Brain, 2021
Axon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various conditions.
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
doaj   +1 more source

GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

eLife, 2016
Axons fail to regenerate after central nervous system (CNS) injury. Modulation of the PTEN/mTORC1 pathway in retinal ganglion cells (RGCs) promotes axon regeneration after optic nerve injury.
Xinzheng Guo, William D Snider, Bo Chen
doaj   +1 more source