Results 31 to 40 of about 769,118 (313)
Frontiers in Bioengineering and Biotechnology, 2020 Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects.
Kritika S. Katiyar +23 more
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Updates and challenges of axon regeneration in the mammalian central nervous system
Journal of Molecular Cell Biology, 2020 Axon regeneration in the mammalian central nervous system (CNS) has been a long-standing and highly challenging issue. Successful CNS axon regeneration will benefit many human diseases involving axonal damage, such as spinal cord injury, traumatic brain ...
Cheng Qian, Feng-Quan Zhou
semanticscholar +1 more source
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway
Acta Neuropathologica Communications, 2022 Wolfram Syndrome (WS) is a fatal human inherited disease with symptoms of diabetes, vision decreasing, and neurodegeneration caused by mutations in the endoplasmic reticulum (ER)-resident protein WFS1.
Zongyi Wang +4 more
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Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration.
Journal of Clinical Investigation, 2020 After trauma, regeneration of adult CNS axons is abortive causing devastating neurologic deficits. Despite progress in rehabilitative care, there is no effective treatment stimulating axon growth following injury. Using models with different regenerative
Rita Pinto-Costa +13 more
semanticscholar +1 more source
rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
PLoS Genetics, 2021 Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues.
Alexander T Lin-Moore +2 more
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Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes [PDF]
, 2020 Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor (NGF), the neurotrophin supporting development of peripheral neurons, as a key player in the time course of ...
arxiv +1 more source
Frontiers in Molecular Neuroscience, 2017 Axon regeneration, fundamental to nerve repair, and functional recovery, relies on rapid changes in gene expression attributable to microRNA (miRNA) regulation.
Rongchen Huang +5 more
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Anomalous diffusion for neuronal growth on surfaces with controlled geometries [PDF]
Published in PLOS ONE, 14(5), e0216181, May 6, 2019, 2019 Geometrical cues are known to play a very important role in neuronal growth and the formation of neuronal networks. Here, we present a detailed analysis of axonal growth and dynamics for neuronal cells cultured on patterned polydimethylsiloxane surfaces.
arxiv +1 more source
Neuronal Alignment On Asymmetric Textured Surfaces [PDF]
Appl. Phys. Lett. 101, 143701 (2012), 2013 Axonal growth and the formation of synaptic connections are key steps in the development of the nervous system. Here we present experimental and theoretical results on axonal growth and interconnectivity in order to elucidate some of the basic rules that neuronal cells use for functional connections with one another.
arxiv +1 more source
F1000Research, 2016 The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
Ngang Heok Tang, Andrew D. Chisholm
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