Results 31 to 40 of about 50,535 (307)
Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration
Frontiers in Neuroscience, 2018 In the nearly 10 years since PTEN was identified as a prominent intrinsic inhibitor of CNS axon regeneration, the PTEN negatively regulated PI3K-AKT-mTOR pathway has been intensively explored in diverse models of axon injury and diseases and its ...
Jie Zhang +5 more
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Guidance Molecules in Axon Regeneration [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue is very limited. Disease or injury that causes destruction or damage to neuronal networks typically results in permanent neurological deficits. Injury to the spinal cord, for example, interrupts vital ascending and descending fiber tracts of spinally projecting ...
Roman J, Giger +2 more
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Molecular Therapy: Nucleic Acids, 2020 Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration after ...
Heather K. Mak +12 more
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F1000Research, 2016 The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
Ngang Heok Tang, Andrew D. Chisholm
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Notch Signaling Inhibits Axon Regeneration [PDF]
Neuron, 2012 Many neurons have limited capacity to regenerate their axons after injury. Neurons in the mammalian central nervous system do not regenerate, and even neurons in the peripheral nervous system often fail to regenerate to their former targets. This failure is likely due in part to pathways that actively restrict regeneration; however, only a few factors ...
El Bejjani, Rachid, Hammarlund, Marc
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BMP signaling in axon regeneration [PDF]
Current Opinion in Neurobiology, 2014 Neuronal competence to re-extend axons and a permissive environment that allows growth cone navigation are two major determinants for successful axon regeneration. Here, we review the roles of bone morphogenetic protein (BMP) signaling in mediating both neuronal and glial injury responses after CNS injury.
Jian, Zhong, Hongyan, Zou
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Synaptic Suppression of Axon Regeneration [PDF]
Neuron, 2016 In this issue of Neuron, Tedeschi et al. (2016) describe the voltage-gated calcium channel subunit alpha2delta2 as a developmental switch from axon elongation to synapse formation and transmission that doubles as a suppressor of axon regeneration, providing a molecular clue for the synaptic stabilization hypothesis of CNS regeneration failure.
Jessica M, Meves, Binhai, Zheng
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Genetic dissection of axon regeneration [PDF]
Current Opinion in Neurobiology, 2011 Axon regeneration has long been studied in vertebrate model organisms and neuronal cultures. Recent development of axon regeneration paradigms in genetic model organisms, such as Caenorhabditis elegans, Drosophila and zebrafish, has opened an exciting field for in vivo functional dissection of regeneration pathways.
Zhiping, Wang, Yishi, Jin
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eLife, 2016 Injured mature CNS axons do not regenerate in mammals. Deletion of PTEN, the negative regulator of PI3K, induces CNS axon regeneration through the activation of PI3K-mTOR signaling.
Linqing Miao +5 more
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Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
eLife, 2023 A key limiting factor of successful axon regeneration is the intrinsic regenerative ability in both the peripheral nervous system (PNS) and central nervous system (CNS).
Dong Wang +7 more
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