Results 11 to 20 of about 8,323 (256)

Modular Access to <i>N</i>-SF₅ Azetidines. [PDF]

J Am Chem Soc
Li R, Hu C, Liu C, Lyness T, Li W, Cai CY, Crossley E, Kanda Y, Merchant RR, Matsuura BS, Williams NS, Qin T.   +11 more
europepmc   +4 more sources

A general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides

Nature Communications, 2022
The construction of four-membered rings via a 4-exo-dig cyclization was originally theorized to be unfavourable and only recently shown in sparse examples.
Clément Jacob, Hajar Baguia, Amaury Dubart, Samuel Oger, Pierre Thilmany, Jérôme Beaudelot, Christopher Deldaele, Stefano Peruško, Yohann Landrain, Bastien Michelet, Samuel Neale, Eugénie Romero, Cécile Moucheron, Veronique Van Speybroeck, Cédric Theunissen, Gwilherm Evano   +15 more
doaj   +2 more sources

Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions

Nature Communications, 2019
The Aza Paternò-Büchi reaction is arguably among the most direct approaches to functionalized azetidines, which are common medicinal scaffolds. Here, the authors report a mild and selective visible light-enabled intramolecular aza Paternò-Büchi reaction ...
Marc R. Becker, Alistair D. Richardson, Corinna S. Schindler   +2 more
doaj   +2 more sources

Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines [PDF]

Angewandte Chemie, 2022
Despite the favorable properties that azetidine rings can engender on drug-compounds, methods for the diversity-oriented synthesis of azetidine-based structures are significantly underdeveloped.
Aggarwal, Varinder Kumar, Noble, Adam, Tyler, Jasper   +2 more
core   +3 more sources

Stereoselective polar radical crossover for the functionalization of strained-ring systems [PDF]

Communications Chemistry
Radical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry.
Florian Trauner, Rahma Ghazali, Jan Rettig, Christina M. Thiele, Dorian Didier   +4 more
doaj   +2 more sources

N-substituted azetidines and other aspects of azetidine chemistry

, 1962
Azetidine has been prepared and its nucleophilicity towards bromoaromatic compounds has been investigated. In this way the synthesis of a number of new N-arylazetidines has been accomplished. The infra red spectra of these azetidines, together with those of a few N-alkylazetidines, prepared from the corresponding 3-aminopropanols, have been compared ...
Gordon Leary
openaire   +4 more sources

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement [PDF]

Journal of the American Chemical Society, 2021
We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a new-to-nature activity of engineered "carbene transferase" enzymes.
David C. Miller, Ravi Lal, Luca Marchetti, Frances H. Arnold   +3 more
openalex   +2 more sources

Radical strain-release photocatalysis for the synthesis of azetidines [PDF]

Nature Catalysis
The increasing popularity of four-member rings in drug discovery has prompted the synthetic chemistry community to advance and reinvent old strategies to craft these structures.
Amati A., Bortolus M., Corti V., Costa P., Dell'Amico L., Natali M., Pelosi G., Rizzo L., Rodríguez R. I., Visentini S.   +9 more
core   +3 more sources

Synthesis of 1,4-Benzodiazepines via Intramolecular C–N Bond Coupling and Ring Opening of Azetidines [PDF]

Molecules
A facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded ...
Xin-Ming Xu, Sen Chen, Shao-Lei Duan, Xiang-Min Wang, Qian Liu, Kai Sun   +5 more
doaj   +2 more sources

Strain-Release-Driven Homologation of Boronic Esters:Application to the Modular Synthesis of Azetidines [PDF]

Journal of the American Chemical Society, 2019
Azetidines are important motifs in medicinal chemistry, but there are a limited number of methods for their synthesis. Herein, we present a new method for their modular construction by exploiting the high ring strain associated with azabicyclo[1.1.0 ...
Aggarwal, Varinder K., Fawcett, Alexander, Gregson, Charlotte H. U., Murtaza, Amna   +3 more
core   +4 more sources