Structural and mechanistic insights into azetidine-associated αKG-NHFe enzyme OkaE with multifunctional catalysis. [PDF]
Nat CommunWang X +18 more
europepmc +2 more sources
Chem Catalysis, 2022 SUMMARY The wide occurrence of enantiopure-fused azetidines in various bioactive molecules leads to a great demand for their efficient synthetic methods. However, so far, organocatalytic protocols have been rather limited.
Leilei Qian +6 more
semanticscholar +1 more source
Molecules, 2013 Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj +1 more source
Diastereoselective Aldol reaction of Zincated 3-Chloro-3-methyl-1-azaallylic anions as key step in the synthesis of 1,2,3,4-Tetrasubstituted 3-Chloroazetidines [PDF]
, 2012 Zincated 3-chloro-3-methyl-1-azaallylic anions undergo a stereoselective aldol addition across aromatic aldehydes and subsequent mesylation to produce syn alpha-chloro-beta-mesyloxyketimines, which were isolated in 80-84% yield and high diastereomeric ...
Catak, Saron +8 more
core +2 more sources
Synthesis of some azetidonone and 1, 3-oxazepine deritives from thymol [PDF]
مجلة التربية والعلم, 2013 A series of some azetidines -2-one derivative (11-16) have been synthesized by cyclocondensation of various hydrazones derivatives (3-10) with chloroacetyl chloride in the presence of triethylamine. Hydrazones (3-10) were synthesized from the reaction of
A. kh. Ahmad, Linda R. Butti
doaj +1 more source
Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones [PDF]
, 2018 Because of the beneficial effect of a trifluoromethyl group on the biological properties of bioactive compounds on the one hand and the versatile synthetic potential of beta-lactams on the other hand, 4-CF3-beta-lactams comprises interesting entities for
D'hooghe, Matthias +2 more
core +1 more source
Novel achievements with an old metal: Copper-promoted synthesis of four-membered azacycles [PDF]
, 2014 The synthesis of four-membered azacycles is of importance because of the chemical and biological relevance of these compounds. Recent progress in copper-catalyzed reactions has been applicable to a variety of research fields, such as heterocyclic ...
Alcaide, Benito +2 more
core +1 more source
Divergent, Strain‐Release Reactions of Azabicyclo[1.1.0]butyl Carbinols:Semipinacol or Spiroepoxy Azetidine Formation [PDF]
, 2021 The azetidine moiety is a privileged motif in medicinal chemistry and new methods that access them efficiently are highly sought after. Towards this goal, we have found that azabicyclo[1.1.0]butyl carbinols, readily obtained from the highly strained ...
Aggarwal, Varinder Kumar +2 more
core +2 more sources
Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross‐Coupling
Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.Reductive cross‐couplings enable efficient C–C bond formation but are limited by the heterogeneity of Zn or costly reagents like TDAE. We report arylhydrazines as inexpensive, convenient reductants for Ni‐catalyzed sp2–sp3 coupling of aryl halides and secondary alkyl iodides. Mechanistic studies support hydrazine‐mediated NiII reduction for a NiI/NiIII
Nils Kurig +5 more
wiley +2 more sources
Chiral donor–acceptor azetines as powerful reactants for synthesis of amino acid derivatives
Nature Communications, 2019 Chiral 3-azetidinones are structural analogues of medicinally relevant β-lactams, however their synthesis and reactivity are underexplored. Here, the authors show a highly enantioselective copper-catalyzed [3 + 1]-cycloaddition generating 2-azetidines ...
Kostiantyn O. Marichev +7 more
doaj +1 more source