Results 11 to 20 of about 5,622 (203)

Dimerization and Isomerization Reactions of α-Lithiated Terminal Aziridines

, 2016
The scope of dimerization and isomerization reactions of α-lithiated terminal aziridines is detailed. Regio- and stereoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (LTMP) or lithium dicyclohexylamide ...
David M. Hodgson (692207), Steven M. Miles (2462320), John G. Ward (2462323), Christopher A. J. Brierley (2462317), Philip G. Humphreys (1357530)   +4 more
core   +8 more sources

Copper-Catalyzed Ring-Opening Reactions of Alkyl Aziridines with B₂pin₂: Experimental and Computational Studies

Molecules, 2021
The possibility to form new C–B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being ...
Lucilla Favero, Andrea Menichetti, Cosimo Boldrini, Lucrezia Margherita Comparini, Valeria Di Bussolo, Sebastiano Di Pietro, Mauro Pineschi   +6 more
doaj   +1 more source

Cooperative chalcogen bonding interactions in confined sites activate aziridines

Nature Communications, 2022
The activation of aziridines is typically achieved via reaction with strong Lewis acids or transition metals. Here, the authors report that cooperative Se ∙ ∙∙O and Se ∙ ∙∙N noncovalent interactions can activate sulfonyl-protected aziridines, which ...
Haofu Zhu, Pan-Pan Zhou, Yao Wang
doaj   +1 more source

Preface to “Aziridine Chemistry” [PDF]

Molecules, 2021
Aziridine is a nitrogen-containing three-membered ring with similar ring strain energy as other three-membered ring compounds, including cyclopropane and oxirane [...]
openaire   +3 more sources

Regioselective and Stereodivergent Synthesis of Enantiomerically Pure Vic-Diamines from Chiral β-Amino Alcohols with 2-Pyridyl and 6-(2,2′-Bipyridyl) Moieties

Molecules, 2020
In this report, we describe the synthetic elaboration of the easily available enantiomerically pure β-amino alcohols. Attempted direct substitution of the hydroxyl group by azido-functionality in the Mitsunobu reaction with hydrazoic acid was ...
Marzena Wosińska-Hrydczuk, Przemysław J. Boratyński, Jacek Skarżewski   +2 more
doaj   +1 more source

The Synthesis of (2R)-Aziridine-2-carboxylic Acid Containing Dipeptides

Acta Chimica Slovenica, 2022
Optimized conditions for the synthesis of fully deprotected (2R)-aziridine containing dipeptides are described. Preparation of fully protected N- and C- terminal aziridine containing dipeptides was found to be straightforward and high yielding for the ...
Samo Kuzmič, Martina Hrast, Rok Frlan
doaj   +1 more source

Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study

Molecules, 2023
An unprecedented oxidative cyclodimerization reaction of 2H-azirine-2-carboxylates to pyrimidine-4,6-dicarboxylates under heating with triethylamine in air is described. In this reaction, one azirine molecule undergoes formal cleavage across the C-C bond
Timofei N. Zakharov, Pavel A. Sakharov, Mikhail S. Novikov, Alexander F. Khlebnikov, Nikolai V. Rostovskii   +4 more
doaj   +1 more source

Access to 2-Fluorinated Aziridine-2-phosphonates from α,α-Halofluorinated β-Iminophosphonates—Spectroscopic and Theoretical Studies

Molecules, 2023
The efficient one-pot halofluorination of a β-enaminophosphonate/β-iminophosphonate tautomeric mixture resulting in α,α-halofluorinated β-iminophosphonates is reported.
Mateusz Klarek, Tomasz Siodła, Tahar Ayad, David Virieux, Magdalena Rapp   +4 more
doaj   +1 more source

Nickel/biimidazole-catalyzed electrochemical enantioselective reductive cross-coupling of aryl aziridines with aryl iodides

Nature Communications, 2023
Here, we report an asymmetric electrochemical organonickel-catalyzed reductive cross-coupling of aryl aziridines with aryl iodides in an undivided cell, affording β-phenethylamines in good to excellent enantioselectivity with broad functional group ...
Yun-Zhao Wang, Zhen-Hua Wang, Inbal L. Eshel, Bing Sun, Dong Liu, Yu-Cheng Gu, Anat Milo, Tian-Sheng Mei   +7 more
doaj   +1 more source

A Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines

SynOpen, 2017
We have developed a new synthetic method for the synthesis of aziridines using Chloramine-T as an effective reagent in the presence of NH2OH·HCl and NaIO4.
Nirnita Chakraborty Ghosal, Sachinta Mahato, Rana Chatterjee, Sougata Santra, Grigory V. Zyryanov, Adinath Majee   +5 more
doaj   +1 more source