Results 31 to 40 of about 28,303 (242)

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses

Redox Biology, 2016
Dietary phenolics may play a protective role in UV-mediated skin pigmentation through their antioxidant and UV-absorbing actions. In this study, we investigated whether genetic silencing of Nrf2, regulating the transcription of antioxidant genes ...
Anyamanee Chaiprasongsuk, Tasanee Onkoksoong, Thanyawan Pluemsamran, Saowalak Limsaengurai, Uraiwan Panich   +4 more
doaj   +1 more source

The Ethanol Extract of Musa sapientum Linn. Peel Inhibits Melanogenesis through AKT Signaling Pathway

Cosmetics, 2021
Hyperpigmentation caused by melanin overproduction can be induced by UV radiation. The quest for effective depigmenting agents continues because many anti-melanin agents have restricted use and/or produce side-effects.
Naphichaya Phacharapiyangkul, Krit Thirapanmethee, Khanit Sa-ngiamsuntorn, Uraiwan Panich, Che-Hsin Lee, Mullika Traidej Chomnawang   +5 more
doaj   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

RETRACTED Overexpressed PKCδ downregulates the expression of PKCα in B16F10 melanoma: induction of apoptosis by PKCδ via ceramide generation.

PLoS ONE, 2014
In the present study, we observed a marked variation in the expression of PKCα and PKCδ isotypes in B16F10 melanoma tumor cells compared to the normal melanocytes.
Kuntal Halder, Sayantan Banerjee, Anamika Bose, Saikat Majumder, Subrata Majumdar   +4 more
doaj   +1 more source

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]

, 2017
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo, Andrey Loboda, Ashani T. Weeraratna, Ayumi Hashimoto, Brian Nam, Butowski, Carus, Challacombe, Chao, Charles Mulligan, Chunsheng Zhang, Condamine, Conway, Coussens, David W. Speicher, DeNardo, Dmitry I. Gabrilovich, Douglas Marvel, Ellen Puré, Fang Wang, Fearon, Feig, Finke, Fred Denstman, Gabrilovich, Gabrilovich, Gascard, Genovese, Gentles, Greenberg, Grivennikov, Guleria, Huang, Kato, Kumar, Ladanyi, Laxminarasimha Donthireddy, Lin, Linda A. Snyder, Lo, Lokeshwar, Lucas, Lucia R. Languino, MacDonald, Manuel A. Sepulveda, Mao, Marlee A. Goins, Messmer, Meyer, Mishra, Mitchem, Mok, Mok, Neil Hockstein, Newman, Noman, Obermajer, Ohno, Orimo, Peter Ordentlich, Pixley, Prashanthi Vonteddu, Pyonteck, Qin Liu, Ramachandran, Reeti Behera, Ries, Ries, Robert H. Vonderheide, Sasse, Sergio Lavilla-Alonso, Shanti Shakamuri, Sionov, Sluijter, Solito, Strachan, Szkandera, Talmadge, Tap, Thomas Condamine, Timothy Chao, Vetsika, Vinit Kumar, Wang, Weber, Xiaowei Xu, Xu, Yang, Zhang, Zhang, Zhu   +90 more
core   +2 more sources

Biodegradable ion-exchange microspheres based on modified polylysines [PDF]

, 1995
Poly-L-lysine was synthesized via a triethylamine initiated ring-opening polymerization of Z-L-lysine-N'~-carboxyanhydride,\ud followed by deprotection of the E-amino group. Subsequently the polylysine was sulfamated using a pyridinium-sulfate complex to
Cremers, H.F.M., Feijen, J., Lens, J.P., Seymour, L.   +3 more
core   +4 more sources

Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma. [PDF]

PLoS ONE, 2012
Melanoma is the most dangerous skin cancer due to its highly metastatic potential and resistance to chemotherapy. Currently, there is no effective treatment for melanoma once it is progressed to metastatic stage. Therefore, further study to elucidate the
Lei Wang, Yu Shi, Peijun Ju, Rui Liu, Siok Ping Yeo, Yinyan Xia, Hamed Owlanj, Zhiwei Feng   +7 more
doaj   +1 more source

(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.

PLoS ONE, 2015
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells.
Jisu Park, Heesung Chung, Seung Hyun Bang, Ah-Reum Han, Eun-Kyoung Seo, Sung Eun Chang, Duk-Hee Kang, Eok-Soo Oh   +7 more
doaj   +1 more source

Novel Genetic Melanoma Vaccines Based on Induced Pluripotent Stem Cells or Melanosphere-Derived Stem-Like Cells Display High Efficacy in a Murine Tumor Rejection Model

Vaccines, 2020
Therapeutic cancer vaccines have elicited renewed interest due to the development of immune checkpoint inhibitors. The role of these vaccines is to induce specific effector cells for killing cancer cells.
Agnieszka Gąbka-Buszek, Eliza Kwiatkowska-Borowczyk, Jakub Jankowski, Anna Karolina Kozłowska, Andrzej Mackiewicz   +4 more
doaj   +1 more source