Results 61 to 70 of about 16,665 (203)

B Cells Promote Tumor Immunity against B16F10 Melanoma [PDF]

The American Journal of Pathology, 2014
B cells are known to be critical mediators of tumor immunity; however, the mechanisms through which they exert this function remain unclear. B-cell linker protein (BLNK) is an essential component of the B-cell antigen receptor signaling machinery and is required for B-cell development, as evidenced by BLNK-deficient (BLNK(-/-)) mice, in which the ...
Tadahiro, Kobayashi, Yasuhito, Hamaguchi, Minoru, Hasegawa, Manabu, Fujimoto, Kazuhiko, Takehara, Takashi, Matsushita   +5 more
openaire   +2 more sources

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth

Molecular Cancer, 2007
Background Angiogenesis is a fundamental process that allows tumor growth by providing nutrients and oxygen to the tumor cells. Beyond the oxygen diffusion limit from a capillary blood vessel, tumor cells become apoptotic.
Juliano Luiz, Juliano Maria A, Monteiro Hugo P, Oliveira Vitor, Rodrigues Elaine G, Carmona Adriana K, Paschoalin Thaysa, Travassos Luiz R   +7 more
doaj   +1 more source

Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling

Marine Drugs, 2022
Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer. Therefore, it is important to develop functional whitening cosmetic reagents that regulate melanogenesis.
Mi Choi, Heejin Lee, Hyoung Kim, Jin Han, Jung Seol, Elena Vasileva, Natalia Mishchenko, Sergey Fedoreyev, Valentin Stonik, Won Ju, Dai-Jin Kim, Sang-Rae Lee   +11 more
openaire   +3 more sources

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

PEX基因对肿瘤细胞生物学性状的影响

Zhongguo shiyan zhenduanxue, 2005
目的　探讨PEX基因在体外对鼠黑色素瘤细胞B16F10生物学性状的影响。方法　利用脂质体介导转染法,经G4 18稳定筛选后,应用MTT、流式细胞术、软琼脂克隆形成实验及Boyden小室侵袭实验,体外观察PEX基因对B16F10细胞生物学性状的影响。结果　BpcDNA sPEX、BpcDNA、B16F10三组细胞生长速度、细胞周期各时相均无明显差异（P >0 . 0 5 ） ;BpcDNA sPEX组细胞集落与BpcDNA组和B16F10组相比统计学上存在显著性差异（P
许传杰, 王贵全, 张立红, 朱桂彬, 王英, 李玉林   +5 more
doaj  

Cystatin C Peptide Effects on B16F10 Melanoma Cells

CellBio, 2021
Background: Metastasis is a major problem for effective therapy of cancer. Small cysteine protease inhibitors, cystatins have been shown to be anti-metastatic for a number of different cancers. We have identified a small peptide of cystatin which exhibits anti-cancer properties for B16 melanoma cells in vitro.
Mathieu Hill, James L. Cox
openaire   +2 more sources

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Effects of heavy ions (12C6+) on malignant melanoma B16F10 cells

Translational Cancer Research, 2022
This study aimed to investigate the effects of heavy ion (12C6+) irradiation on the proliferation, apoptosis, cell cycle, migration, and epithelial-mesenchymal transition (EMT) of B16F10 cells.The B16F10 cells, which is a malignant melanoma cell line widely used in research, irradiated by 12C6+ and X-ray were detected by Hoechst 33342/propidium iodide ...
Zhang, Li-Ping, Li, Sha, Zhang, Hong, Li, Qiang, Liu, Yang, Li, Fei-Fei, Gong, Da-Jie   +6 more
openaire   +2 more sources

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source