Results 71 to 80 of about 28,303 (242)
Advanced Science, EarlyView.This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren +5 more
wiley +1 more source
Molecular Cancer, 2007 Background Angiogenesis is a fundamental process that allows tumor growth by providing nutrients and oxygen to the tumor cells. Beyond the oxygen diffusion limit from a capillary blood vessel, tumor cells become apoptotic.
Juliano Luiz +7 more
doaj +1 more source
Advanced Science, EarlyView.A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu +8 more
wiley +1 more source
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]
, 2019 Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E. +10 more
core +1 more source
Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity [PDF]
, 2013 Efficacy of antitumor vaccination depends to a large extent on antigen targeting to dendritic cells (DCs). Here, we assessed antitumor immunity induced by attenuated coronavirus vectors which exclusively target DCs in vivo and express either lymphocyte ...
A Marabelle +59 more
core +3 more sources
Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling
Marine Drugs, 2022 Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer. Therefore, it is important to develop functional whitening cosmetic reagents that regulate melanogenesis.
Mi Choi +11 more
openaire +3 more sources
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2005 目的 探讨PEX基因在体外对鼠黑色素瘤细胞B16F10生物学性状的影响。方法 利用脂质体介导转染法,经G4 18稳定筛选后,应用MTT、流式细胞术、软琼脂克隆形成实验及Boyden小室侵袭实验,体外观察PEX基因对B16F10细胞生物学性状的影响。结果 BpcDNA sPEX、BpcDNA、B16F10三组细胞生长速度、细胞周期各时相均无明显差异（P >0 . 0 5 ） ;BpcDNA sPEX组细胞集落与BpcDNA组和B16F10组相比统计学上存在显著性差异（P
许传杰 +5 more
doaj
Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity [PDF]
, 2008 Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of amines ...
Dehshahri, Ali +3 more
core +1 more source
Effects of heavy ions (12C6+) on malignant melanoma B16F10 cells
Translational Cancer Research, 2022 This study aimed to investigate the effects of heavy ion (12C6+) irradiation on the proliferation, apoptosis, cell cycle, migration, and epithelial-mesenchymal transition (EMT) of B16F10 cells.The B16F10 cells, which is a malignant melanoma cell line widely used in research, irradiated by 12C6+ and X-ray were detected by Hoechst 33342/propidium iodide ...
Zhang, Li-Ping +6 more
openaire +2 more sources