Results 91 to 100 of about 28,303 (242)

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Inclusion of ΑVβ3 integrin into extracellular vesicles in a caveolin-1 tyrosine-14- phosphorylation dependent manner and subsequent transfer to recipient melanoma cells promotes migration, invasion and metastasis

Cell Communication and Signaling
Caveolin-1 (CAV1) is a membrane protein that promotes migration, invasion and metastasis of cancer cells when phosphorylated on tyrosine-14 (Y14) by a cell intrinsic mechanism involving the activation of a novel Rab5-Rac1 signaling axis.
R. Huilcaman, A. Campos, P. Contreras, L. Simón, M. Varas-Godoy, F. Grünenwald, Baohai Shao, Jay Heinecke, L. Lobos-Gonzalez, L. Leyton, A. F. G. Quest   +10 more
doaj   +1 more source

A novel mode of capping protein-regulation by Twinfilin [PDF]

, 2018
Cellular actin assembly is controlled at the barbed ends of actin filaments, where capping protein (CP) limits polymerization. Twinfilin is a conserved in vivo binding partner of CP, yet the significance of this interaction has remained a mystery.
Amarasinghe, Gaya K, Cooper, John A, Goode, Bruce L, Harris, Meghan T, Hilton, Denise M, Johnson, Britney, Johnston, Adam B, McConnell, Patrick, Simone, Avital   +8 more
core   +1 more source

Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor [PDF]

, 2014
Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs ...
Al-Hassani, Mohammed, Althouse, Sandra K., Ferracini, Matheus, Harrison, Kathleen A., Konger, Raymond L., Loesch, Mathew, Murphy, Robert C., Ocana, Jesus A., Perkins, Susan M., Sahu, Ravi P., Speicher, Paul J., Sun, Louis, Touloukian, Christopher E., Travers, Jeffrey B., Tyler, Douglas S.   +14 more
core   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent.

PLoS ONE, 2009
BackgroundWe report here the isolation and characterization of a new compound Ailanthus excelsa chloroform extract-1 (AECHL-1) (C(29)H(36)O(10); molecular weight 543.8) from the root bark of Ailanthus excelsa Roxb.
Manish S Lavhale, Santosh Kumar, Shri Hari Mishra, Sandhya L Sitasawad   +3 more
doaj   +1 more source

Epidermal PPARγ influences subcutaneous tumor growth and acts through TNF-α to regulate contact hypersensitivity and the acute photoresponse [PDF]

, 2017
It is known that ultraviolet B (UVB) induces PPARγ ligand formation while loss of murine epidermal PPARγ (Pparg-/-epi) promotes UVB-induced apoptosis, inflammation, and carcinogenesis. PPARγ is known to suppress tumor necrosis factor-α (TNF-α) production.
Derr-Yellin, Ethel, Konger, Raymond L., Ocana, Jesus A., Sahu, Ravi P., Travers, Jeffrey B.   +4 more
core   +1 more source

Inhibitory effects of different fractions of Nepeta satureioides on melanin synthesis through reducing oxidative stress

Research in Pharmaceutical Sciences, 2017
Nepeta satureioides Boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n-hexane and dichloromethane (CH2Cl2) fractions of the ...
Seyed Ahmad Emami, Rezvan Yazdian-Robati, Mohammad Sadeghi, Javad Baharara, Elaheh Amini, Farzaneh Salek, Zahra Tayarani-Najaran   +6 more
doaj   +1 more source

Antimicrobial, antioxidant and anti-tyrosinase properties of extracts of the Mediterranean parasitic plant Cytinus hypocistis [PDF]

, 2015
Background: Cytinus is an endophytic parasitic plant occurring in South Africa, Madagascar, and in the Mediterranean region. We have extracted the inflorescences (the only visible part of the plant, emerging from the host roots at the time of blossom) of
Manzo, Giorgia, Nieddu, Mariella, Pintus, Manuela, Rinaldi, Andrea, Steri, Daniela, Zucca, Paolo   +5 more
core   +1 more source

Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer [PDF]

, 2012
Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 ...
Alizadeh, A., Ghaemi, A., Gorji, A., Moradi, A., Razeghi, S., Soleimanjahi, H., Tabaraei, A., Vakili, M.A.   +7 more
core   +1 more source