Results 221 to 230 of about 1,958,602 (263)

Organisation of B-cell receptors on the cell membrane

IEE Proceedings - Systems Biology, 2006
B-cell receptors (BCRs) have been reported to organise into oligomeric clusters on the B-cell surface, and mutations, that are likely to interfere with such clustering, result in B-cell unresponsiveness. This has led to the suggestion that pre-formed BCR clusters may be crucial for B-cell signalling.
Iber, D., Gruhn, T.
openaire   +3 more sources

Receptor Editing in B Cells

1999
Publisher Summary This chapter reviews the essential facts related to the organization of immunoglobulin genes, V(D)J recombination, and B-cell development. The chapter also presents how signals from the antigen receptor influence gene rearrangements during development, tolerance-induction, and immunity.
openaire   +2 more sources

Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells

Immunological Reviews, 2000
Summary: During B‐cell development the surrogate light (SL) chain is selectively expressed in progenitor and precursor B cells during the developmental stages of DH to JH and VH to DH JH rearrangements. Approximately half of all H chains produced by these rearrangements cannot pair with SL chains and cannot form a pre‐B‐cell receptor (pre‐BCR).
F, Melchers, E, ten Boekel, T, Seidl, X C, Kong, T, Yamagami, K, Onishi, T, Shimizu, A G, Rolink, J, Andersson   +8 more
openaire   +2 more sources

The B-cell antigen receptor complex

Immunology Today, 1991
Abstract Here, Michael Reth, John Cambier and colleagues review the genetics, biochemistry and cell biology o f the recently-identified accessory components o f the B-cell antigen receptor.
M, Reth, J, Hombach, J, Wienands, K S, Campbell, N, Chien, L B, Justement, J C, Cambier   +6 more
openaire   +2 more sources

Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas

2012
Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, "stereotyped" immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequences within their B cell receptors (BcR), suggesting selection by common epitopes or classes of ...
Nikos, Darzentas, Kostas, Stamatopoulos
openaire   +2 more sources

Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas

2019
Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG.
Andreas, Agathangelidis, Fotis, Psomopoulos, Kostas, Stamatopoulos   +2 more
openaire   +2 more sources

B cell receptor signaling and autoimmunity

The FASEB Journal, 2001
The immune receptors of lymphocytes are able to sense the nature of bound ligands. Through coupled signaling pathways the generated signals are appropriately delivered to the intracellular machinery, allowing specific functional responses.
P, Hasler, M, Zouali
openaire   +2 more sources

B Cell Receptor and Antigens in CLL

2013
Nowadays, chronic lymphocytic leukemia (CLL) is considered as a prototypic antigen-driven lymphoma, with antigenic stimuli from the microenvironment promoting tumor outgrowth. Antigen recognition is a function of both the clonotypic B cell receptor immunoglobulin (BcR IG) and various other immune sensors, e.g., the Toll-like receptors.
Andreas, Agathangelidis, Stavroula, Ntoufa, Kostas, Stamatopoulos   +2 more
openaire   +2 more sources

The abnormal signaling of the B cell receptor and co-receptors of lupus B cells

Clinical Immunology
It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a "B cell disease". Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune ...
openaire   +2 more sources

B-Cell Receptors

2018
What does the BCR do and why is it critical in normal B-cell development? What is its role in B-cell maturation and the biological responses including activation, tolerance, and/or differentiation? What is its role in CLL? Here, the focus is on the current understanding of the BCR signal cascade in normal B cells and its altered path in CLL that ...
openaire   +1 more source