Results 231 to 240 of about 1,740,499 (263)

Receptor Editing in B Cells

1999
Publisher Summary This chapter reviews the essential facts related to the organization of immunoglobulin genes, V(D)J recombination, and B-cell development. The chapter also presents how signals from the antigen receptor influence gene rearrangements during development, tolerance-induction, and immunity.
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B-Cell Receptors

2018
What does the BCR do and why is it critical in normal B-cell development? What is its role in B-cell maturation and the biological responses including activation, tolerance, and/or differentiation? What is its role in CLL? Here, the focus is on the current understanding of the BCR signal cascade in normal B cells and its altered path in CLL that ...
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Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas

2012
Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, "stereotyped" immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequences within their B cell receptors (BcR), suggesting selection by common epitopes or classes of ...
Nikos Darzentas, Kostas Stamatopoulos
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B cell receptor signaling and autoimmunity

The FASEB Journal, 2001
The immune receptors of lymphocytes are able to sense the nature of bound ligands. Through coupled signaling pathways the generated signals are appropriately delivered to the intracellular machinery, allowing specific functional responses. A central issue in contemporary immunology is how the fate of B lymphocytes is determined at the successive ...
Moncef Zouali, Paul Hasler
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Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells

Immunological Reviews, 2000
Summary: During B‐cell development the surrogate light (SL) chain is selectively expressed in progenitor and precursor B cells during the developmental stages of DH to JH and VH to DH JH rearrangements. Approximately half of all H chains produced by these rearrangements cannot pair with SL chains and cannot form a pre‐B‐cell receptor (pre‐BCR).
Tamotsu Yamagami, Fritz Melchers, Jan Andersson, Takeyuki Shimizu, Antonius Rolink, Kazuo Onishi, Edwin ten Boekel, Xian Chu Kong, Thomas Seidl   +8 more
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T‐cell receptor genes expression in B‐cell leukaemias

British Journal of Haematology, 1989
Summary. Using Northern‐blot analysis we have studied the expression of T‐cell receptor (TCR) α, β and γ chain genes in primary cells obtained from 36 leukaemic patients. Fifteen patients had myeloid leukaemias, two had T‐cell leukaemias, and 19 leukaemias corresponding to various stages of B‐lymphocyte differentiation.
NARNI, Franco, M. T. MARIANO, A. COL, M. GRANTINI, F. MERLI, A. DONELLI, G. MONTAGNANI, DI PRISCO, Alfredo Ubaldo, TORELLI, Giuseppe, TORELLI, Umberto   +9 more
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B Cell Receptor Togetherness

Science Signaling, 2010
Activation of the B cell receptor appears to require release of the receptors from an autoinhibited, oligomeric state.
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Idiotypes, T-Cell Receptors, and T-B Cooperation

1980
T cells are responsible for virtually all the characteristics of the mammalian immune system except the production of serum antibody, in which they play a vital regulatory role. As such, they are central to our understanding of the immune system. T cells recognize cell-bound antigens with great precision, in association with self MHC antigens.
Charles A. Janeway, Charles A. Janeway
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The abnormal signaling of the B cell receptor and co-receptors of lupus B cells

Clinical Immunology
It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a "B cell disease". Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune ...
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B cell receptor signal strength determines B cell fate

Nature Immunology, 2004
B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions. Here, we used the Epstein-Barr virus protein LMP2A as a constitutively active BCR surrogate to study the contribution of BCR signal strength in B cell differentiation.
Jeffery L. Kutok, Sibille Humme, Sibille Humme, Kevin L. Otipoby, Marat Alimzhanov, Nathalie Uyttersprot, Stefano Casola, Stefano Casola, Michael C. Carroll, Klaus Rajewsky, Klaus Rajewsky   +10 more
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