Results 61 to 70 of about 1,943,316 (288)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Trade-Offs between Competitive Ability and Resistance to Top-Down Control in Marine Microbes

mSystems, 2023
Trade-offs between competitive ability and resistance to top-down control manifest the “kill-the-winner” hypothesis that explains how mortality caused by protists and viruses can promote bacterial diversity.
Jinny Wu Yang, Feng-Hsun Chang, Yi-Chun Yeh, An-Yi Tsai, Kuo-Ping Chiang, Fuh-Kwo Shiah, Gwo-Ching Gong, Chih-hao Hsieh   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Bacterial endophytes enhance competition by invasive plants

American Journal of Botany, 2013
• Premise of the study: Invasive plants can alter soil microbial communities and profoundly alter ecosystem processes. In the invasive grass Sorghum halepense, these disruptions are consequences of rhizome‐associated bacterial endophytes. We describe the effects of N2‐fixing bacterial strains from S.
Marnie E, Rout, Thomas H, Chrzanowski, Tara K, Westlie, Thomas H, DeLuca, Ragan M, Callaway, William E, Holben   +5 more
openaire   +3 more sources

Bacterial competition as a means of preventing neonatal diarrhea in pigs [PDF]

Infection and Immunity, 1976
Baby pigs orally inoculated with a porcine strain of enterotoxigenic Escherichia coli (K88+,Ent+) showed signs of depression, severe diarrhea, and, in some instances, death. Few, if any, signs of illness occurred if baby pigs were first inoculated with a K88 possessing non-enterotoxin-producing strain of E. coli.
J N, Davidson, D C, Hirsh
openaire   +2 more sources

A fluorescence-based protocol to monitor bacterial antagonism

Microbiology Spectrum
Bacteria are often found in polymicrobial communities where competition for limited space and resources drives antagonistic interactions. Therefore, bacteria have evolved various antibacterial weapons to outcompete their neighbors.
Justin M. Luu, Cristian V. Crisan, Morgan L. Pettis, Anayancy Ramos Facio, Timothy D. Read, Joanna B. Goldberg   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Acinetobacter nosocomialis utilizes a unique type VI secretion system to promote its survival in niches with prey bacteria

mBio
Pathogenic bacteria of the Acinetobacter genus pose a severe threat to human health worldwide due to their strong adaptability, tolerance, and antibiotic resistance.
Yu Sun, Lidong Wang, Ming Zhang, Jing Jie, Qingtian Guan, Jiaqi Fu, Xiao Chu, Dong Chen, Chunxiuli Li, Lei Song, Zhao-Qing Luo   +10 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source