Results 61 to 70 of about 2,038,554 (284)

Role of competition for substrate in bacterial antagonism in the gut [PDF]

Infection and Immunity, 1982
Small slices of agar, each containing about 10(5.5) Escherichia coli organisms, were preincubated either in the contents of rat cecum or in brain heart infusion broth for 2 h and then were transferred to a small sample of saline. The purpose of these experiments was to examine the ability of E.
openaire   +2 more sources

Leveraging strain competition to address antimicrobial resistance with microbiota therapies

Gut Microbes
The enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as fecal ...
Danielle Barrios Steed, Dylan Koundakjian, Anthony D. Harris, Adriana E Rosato, Konstantinos T Konstantinidis, Michael H Woodworth   +5 more
doaj   +1 more source

Bacteria-Killing Type IV Secretion Systems

Frontiers in Microbiology, 2019
Bacteria have been constantly competing for nutrients and space for billions of years. During this time, they have evolved many different molecular mechanisms by which to secrete proteinaceous effectors in order to manipulate and often kill rival ...
Germán G. Sgro, Gabriel U. Oka, Diorge P. Souza, William Cenens, Ethel Bayer-Santos, Bruno Y. Matsuyama, Natalia F. Bueno, Thiago Rodrigo dos Santos, Cristina E. Alvarez-Martinez, Roberto K. Salinas, Chuck S. Farah   +10 more
doaj   +1 more source

Is bacterial persistence a social trait? [PDF]

, 2007
All three authors are supported by Royal Society fellowships.The ability of bacteria to evolve resistance to antibiotics has been much reported in recent years. It is less well-known that within populations of bacteria there are cells which are resistant
Andy Gardner, West, Stuart A., Griffin, Ashleigh S., Ashleigh S Griffin, Stuart A West, Gardner, Andy   +5 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system [PDF]

The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system’s dependency on contact, cellular interactions can lead to either competition or kin protection.
Blokesch, Melanie, Lemopoulos, Alexandre, Servajean, Richard Marie, Bitbol, Anne-Florence, Otto, Simon Bernhard   +4 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Bacterial endophytes enhance competition by invasive plants

American Journal of Botany, 2013
• Premise of the study: Invasive plants can alter soil microbial communities and profoundly alter ecosystem processes. In the invasive grass Sorghum halepense, these disruptions are consequences of rhizome‐associated bacterial endophytes. We describe the effects of N2‐fixing bacterial strains from S.
Marnie E, Rout, Thomas H, Chrzanowski, Tara K, Westlie, Thomas H, DeLuca, Ragan M, Callaway, William E, Holben   +5 more
openaire   +3 more sources

Bacterial competition as a means of preventing neonatal diarrhea in pigs [PDF]

Infection and Immunity, 1976
Baby pigs orally inoculated with a porcine strain of enterotoxigenic Escherichia coli (K88+,Ent+) showed signs of depression, severe diarrhea, and, in some instances, death. Few, if any, signs of illness occurred if baby pigs were first inoculated with a K88 possessing non-enterotoxin-producing strain of E. coli.
J N, Davidson, D C, Hirsh
openaire   +2 more sources