Results 131 to 140 of about 1,037,544 (299)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A Framework for collaborative writing with recording and post-meeting retrieval capabilities [PDF]
, 2004 From a HCI perspective, elucidating and supporting the context in which collaboration takes place is key to implementing successful collaborative systems.
Bouamrane, Matt-Mouley +3 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Editing OWL through generated CNL [PDF]
, 2009 . Traditionally, Controlled Natural Languages (CNLs) are de-signed either to avoid ambiguity for human readers, or to facilitate auto-matic semantic analysis, so that texts can be transcoded to a knowledge representation language. CNLs of the second kind
Power, Richard +3 more
core +1 more source
Soil alkalinity and cotton production: Challenges, physiological effects, and sustainable solutions
Plant StressAlkali stress, marked by high soil pH (>8.5) and excess sodium bicarbonate/carbonate, threatens global cotton productivity, especially in arid regions.
Atif Raja +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Establishment of an Efficient Protoplast-Based Base Editing Platform in Lettuce
AgronomyLettuce (Lactuca sativa L.) is an important leafy vegetable crop, yet the efficiency and reliability of genome editing platforms in lettuce remain limited, particularly for precision base editing applications.
Yu Jia, Guo Peng, Qiang Zhou
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cytosine base editor-DNA binding domain fusions for editing window modulation in the RNP format
BMC BiotechnologySummary Base editing technologies allow for the precise and efficient installation of defined nucleotide substitutions into a target genome without the introduction of double strand breaks or DNA templates.
Erin Brettmann +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source