Results 211 to 220 of about 510,395 (260)

Research progress of base editing and prime editing tools based on the CRISPR/Cas system. [PDF]

Mol Ther Nucleic Acids
Gao H, Gao S, Kan G, Valentovich LN, An Y.   +4 more
europepmc   +1 more source

Comparative analysis of CRISPR-Cas9, lentiviral transduction, and base editing for sickle cell disease in a murine model. [PDF]

Blood Adv
Butt H, Sathish S, London E, Le A, Li Q, Gudmundsdottir B, Lee DY, Burke EV, Yates BP, Liu DR, Hsieh M, Leonard A, Eaton WA, Uchida N, Pierciey FJ, Newby GA, Tisdale JF, Demirci S.   +17 more
europepmc   +1 more source

Base editing strategies for <i>in vivo</i> correction of two highly recurrent phenylketonuria variants. [PDF]

Mol Ther Nucleic Acids
Quigley A, Jindal I, Campion T, Rutherford D, Han Y, Quigley W, Qu P, Musunuru K, Ahrens-Nicklas R, Hong X, Wang X.   +10 more
europepmc   +1 more source

PRPF8 Mutation-Induced Defects in Human iPSC-Derived RPE Are Rescued by Adenine Base Editing. [PDF]

Invest Ophthalmol Vis Sci
Sun X, Liang Y, Liang Y, Li W, Chen H, Ding C, Duan C, Zhou Y, Zhang R, Xu H, Chen J.   +10 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Base Editing in Progeria

New England Journal of Medicine, 2021
Extending Life Span in a Mouse Model of Progeria The Hutchinson–Gilford progeria syndrome is an autosomal dominant disease caused by a single point mutation in LMNA, which encodes the lamin A and C...
Jin-Soo, Kim, Maria, Eriksson
openaire   +2 more sources

A Review on Advanced CRISPR-Based Genome-Editing Tools: Base Editing and Prime Editing

Molecular Biotechnology, 2022
In the field of medicine, it is axiomatic that the need of a precise gene-editing tool is critical to employ therapeutic approaches toward pathogenic mutations, occurring in human genome. Today we know that most of genetic defects are caused by single-base pair substitutions in genomic DNA.
Ali Saber Sichani, Maryam Ranjbar, Maryam Baneshi, Farid Torabi Zadeh, Jafar Fallahi   +4 more
openaire   +2 more sources

CRISPR-Cas9 DNA Base-Editing and Prime-Editing [PDF]

International Journal of Molecular Sciences, 2020
Many genetic diseases and undesirable traits are due to base-pair alterations in genomic DNA. Base-editing, the newest evolution of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based technologies, can directly install point-mutations in cellular DNA without inducing a double-strand DNA break (DSB).
Michelle Mcclements, Robert Maclaren, Mark M Hassall   +2 more
exaly   +3 more sources

Base editing goes into hyperdrive

Nature Cell Biology, 2020
CRISPR base editors can induce single-base-pair changes in the genome, although they are often inefficient. A study now shows that fusion of the DNA-binding domain of RAD51 to base editors enhances both the efficiency and the targeting range of optimized enzymes. These ‘hyper-editors’ offer effective tools for disease modeling and gene therapy.
Alyna Katti, Lukas E. Dow
openaire   +2 more sources

Symmetry-based photo-editing

Pattern Recognition, 2003
In this paper, we demonstrate how to edit digital photos based on the understanding of high-level geometric knowledge imposed upon objects in the photos. This is achieved by the correct recovery of the 3-D shape and relationships of the objects, without explicitly performing full 3-D reconstruction.
Kun Huang 0001, Wei Hong 0003, Yi Ma 0001   +2 more
openaire   +1 more source

Cytosine Base Editing in Bacteria

2023
Base editing is a new genome editing technology that enables DNA base mutations without requiring double-stranded DNA backbone cleavage or a donor template. It has been widely used for genome engineering of eukaryotic and prokaryotic microorganisms.
Ye, Liu, Yang, Liu, Ping, Zheng, Yu, Wang, Meng, Wang   +4 more
openaire   +2 more sources