Results 31 to 40 of about 59,389 (246)

A Caspase-Resistant Form of Bcl-XL, but Not Wild Type Bcl-XL, Promotes Clonogenic Survival After Ionizing Radiation

Neoplasia: An International Journal for Oncology Research, 1999
Bcl-2 and Bcl-XL belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation.
Alnawaz Rehemtulla, A. Christin Hamilton, Neelam Taneja, Jordan Fridman, Todd S.C. Juan, Jonathan Maybaum, Arul Chinnaiyan   +6 more
doaj   +1 more source

Restoring Bcl-xL levels benefits a mouse model of spinal muscular atrophy

Neurobiology of Disease, 2008
Currently, no curative treatment is available for spinal muscular atrophy (SMA). Since the degeneration of spinal motor neurons in SMA is mediated by apoptosis, over-expression of an anti-apoptotic factor, Bcl-xL, may benefit SMA.
Li-Kai Tsai, Ming-Shiun Tsai, Chen-Hung Ting, Sue-Hong Wang, Hung Li   +4 more
doaj   +1 more source

SENP3 Promotes an Mff-Primed Bcl-xL-Drp1 Interaction Involved in Cell Death Following Ischemia

Frontiers in Cell and Developmental Biology, 2021
Dysregulation of the mitochondrial fission machinery has been linked to cell death following ischemia. Fission is largely dependent on recruitment of Dynamin-related protein 1 (Drp1) to the receptor Mitochondrial fission factor (Mff) located on the ...
Chun Guo, Keri L. Hildick, Juwei Jiang, Alice Zhao, Wenbin Guo, Jeremy M. Henley, Jeremy M. Henley, Kevin A. Wilkinson   +7 more
doaj   +1 more source

Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and ApoptosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Bcl-xL, an anti-apoptotic Bcl-2 family protein, is overexpressed in 90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, Bcl-xL expression in pancreatic intraepithelial neoplasias (PanINs) and its significance in PDAC ...
Kenji Ikezawa, Hayato Hikita, Minoru Shigekawa, Kiyoshi Iwahashi, Hidetoshi Eguchi, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara   +7 more
doaj   +1 more source

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Nature Communications, 2021
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectively ...
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou   +23 more
doaj   +1 more source

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma [PDF]

British Journal of Cancer, 2013
Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcinoma (UC) cells.We evaluated the ...
Yoshimine, S, Kikuchi, E, Kosaka, T, Mikami, S, Miyajima, A, Okada, Y, Oya, M   +6 more
openaire   +2 more sources

Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System

Biomolecules, 2023
The antiapoptotic protein Bcl-xL is a major regulator of cell death and survival, but many aspects of its functions remain elusive. It is mostly localized in the mitochondrial outer membrane (MOM) owing to its C-terminal hydrophobic α-helix.
Akandé Rouchidane Eyitayo, Axel Boudier-Lemosquet, Stéphane Chaignepain, Muriel Priault, Stéphen Manon   +4 more
doaj   +1 more source

Deamidation of Bcl-XL [PDF]

Molecular Cell, 2002
Bcl-2 proteins are critical regulators of apoptosis following DNA damage. Recent studies have shown that genotoxic stress induces the deamidation of Bcl-X(L), inhibiting its antiapoptotic activities. Remarkably, Rb and p53 are important regulators of this novel modification of Bcl-X(L).
openaire   +1 more source

Regulation of Bcl-xl Channel Activity by Calcium [PDF]

Journal of Biological Chemistry, 1998
Recent studies have demonstrated that the anti-apoptotic proteins, Bcl-2 and Bcl-xl, with the carboxyl-terminal hydrophobic domain removed, form cation-selective channels in the lipid bilayer reconstitution system. However, the regulatory properties of these channels are unknown.
Minh Lam, Manjunatha B. Bhat, Gabriel Núñez, Jianjie Ma, Clark Distelhorst   +4 more
openalex   +4 more sources

De novo pyrimidine biosynthesis inhibition synergizes with BCL-X_L targeting in pancreatic cancer. [PDF]

Nat Commun
Zhang H, Santana-Codina N, Yu Q, Poupault C, Campos C, Qin X, Sindoni N, Ciscar M, Padhye A, Kuljanin M, Wang J, Dorman MJ, Bross P, Aguirre AJ, Dougan SK, Sarosiek KA, Mancias JD.   +16 more
europepmc   +3 more sources