Results 31 to 40 of about 95,261 (258)

Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL

Neoplasia: An International Journal for Oncology Research, 2001
Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-XL compared with ...
Raj. S. Mitra, Mary A. Benedict, Dalong Qian, Kimberly E. Foreman, Daryoush Ekhterae, Brian J. Nickoloff, Gabriel Nuñez   +6 more
doaj   +1 more source

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain [PDF]

, 2015
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2+-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors ...
Bultynck, Geert, De Smedt, Humbert, Decrock, Elke, Ivanova, Hristina, Kasri, Nael Nadif, Lemmens, Irma, Leybaert, Luc, Martens, Lennart, Missiaen, Ludwig, Monaco, Giovanni, Parys, Jan B, Sorrentino, Vincenzo, Tavernier, Jan, Vandermarliere, Elien, Vervliet, Tim   +14 more
core   +1 more source

Restoring Bcl-xL levels benefits a mouse model of spinal muscular atrophy

Neurobiology of Disease, 2008
Currently, no curative treatment is available for spinal muscular atrophy (SMA). Since the degeneration of spinal motor neurons in SMA is mediated by apoptosis, over-expression of an anti-apoptotic factor, Bcl-xL, may benefit SMA.
Li-Kai Tsai, Ming-Shiun Tsai, Chen-Hung Ting, Sue-Hong Wang, Hung Li   +4 more
doaj   +1 more source

SENP3 Promotes an Mff-Primed Bcl-xL-Drp1 Interaction Involved in Cell Death Following Ischemia

Frontiers in Cell and Developmental Biology, 2021
Dysregulation of the mitochondrial fission machinery has been linked to cell death following ischemia. Fission is largely dependent on recruitment of Dynamin-related protein 1 (Drp1) to the receptor Mitochondrial fission factor (Mff) located on the ...
Chun Guo, Keri L. Hildick, Juwei Jiang, Alice Zhao, Wenbin Guo, Jeremy M. Henley, Jeremy M. Henley, Kevin A. Wilkinson   +7 more
doaj   +1 more source

Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and ApoptosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Bcl-xL, an anti-apoptotic Bcl-2 family protein, is overexpressed in 90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, Bcl-xL expression in pancreatic intraepithelial neoplasias (PanINs) and its significance in PDAC ...
Kenji Ikezawa, Hayato Hikita, Minoru Shigekawa, Kiyoshi Iwahashi, Hidetoshi Eguchi, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara   +7 more
doaj   +1 more source

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin [PDF]

, 2009
Background: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage
Brundin, Patrick, Khoshnan, Ali, Ko, Jan, Patterson, Paul H., Tescu, Simona   +4 more
core   +3 more sources

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Nature Communications, 2021
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectively ...
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou   +23 more
doaj   +1 more source

Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System

Biomolecules, 2023
The antiapoptotic protein Bcl-xL is a major regulator of cell death and survival, but many aspects of its functions remain elusive. It is mostly localized in the mitochondrial outer membrane (MOM) owing to its C-terminal hydrophobic α-helix.
Akandé Rouchidane Eyitayo, Axel Boudier-Lemosquet, Stéphane Chaignepain, Muriel Priault, Stéphen Manon   +4 more
doaj   +1 more source

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl [PDF]

, 2012
Antiapoptotic B-cell lymphoma 2 (Bcl-2) targets the inositol 1,4,5-trisphosphate receptor (IP3R) via its BH4 domain, thereby suppressing IP3R Ca2+-flux properties and protecting against Ca2+-dependent apoptosis. Here, we directly compared IP3R inhibition
A Spat, AE Palmer, C Li, C Li, C W Distelhorst, C White, CJ Hanson, D Boehning, D Boehning, DC Huang, E De Vuyst, E Decrock, E Decrock, EF Eckenrode, F Zhong, F Zhong, G Bathori, G Bultynck, G Csordas, G Monaco, H Akl, H De Smedt, I Kruman, J B Parys, JE Chipuk, JE Chipuk, JJ Hunter, JK Brunelle, JK Foskett, JP Decuypere, JP Decuypere, KS Putt, L Leybaert, L Missiaen, L Scorrano, LC Lee, LK Nutt, M De Maeyer, P Pinton, R Chen, R Ponsaerts, R Ponsaerts, R Rizzuto, RG Jones, S Cory, S Shimizu, SA Oakes, SA Oakes, SA Oakes, SK Joseph, SW Muchmore, T Hayashi, T Kaufmann, T Luyten, T Vervliet, U Bertsch, Y Rong, YP Rong, YP Rong, YP Rong   +59 more
core   +2 more sources

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma [PDF]

British Journal of Cancer, 2013
Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcinoma (UC) cells.We evaluated the ...
Yoshimine, S, Kikuchi, E, Kosaka, T, Mikami, S, Miyajima, A, Okada, Y, Oya, M   +6 more
openaire   +2 more sources