Results 91 to 100 of about 8,288 (202)

Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4 [PDF]

Diabetes, 2017
Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through de novo adipogenesis; however, how “beiging” characteristics are maintained afterward is largely ...
Yangmeng Wang, Esther Paulo, Dongmei Wu, Yixuan Wu, Wendong Huang, Ajay Chawla, Biao Wang   +6 more
openaire   +4 more sources

The DMHGABA Neurons Play a Crucial Role in the Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

Advanced Science, Volume 13, Issue 5, 27 January 2026.
GABAergic neurons in the dorsomedial hypothalamus (DMHGABA neurons) act as a key neuronal population controlling cold exposure‐induced white adipose tissue browning. DMHGABA neurons regulate the browning through DMH to the lateral preoptic area (LPO) projection.
Zhijie Su, Yujia Hou, Bingwei Wang, Qian Zhou, Wen Yang, Bingbing Guo, Chenyu Zhang, Miao Zhao, Xiaoning Yang, Jiarui Liu, Xiangyang Xie, Lihua Qin, Weiguang Zhang, Wei L. Shen, Ruimao Zheng   +14 more
wiley   +1 more source

Induction of Beige-Like Adipocytes in 3T3-L1 Cells

Journal of Veterinary Medical Science, 2014
There are two types of brown adipocytes: classical brown adipocytes that form the brown fat depots and beige adipocytes that emerge in the white fat depots. Beige adipocytes have a low level of uncoupling protein 1 (Ucp1) expression in the basal state, but Ucp1 expression is increased in response to β adrenergic receptor activation.
ASANO, Hiroki, KANAMORI, Yohei, HIGURASHI, Satoshi, NARA, Takayuki, KATO, Ken, MATSUI, Tohru, FUNABA, Masayuki   +6 more
openaire   +3 more sources

Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity

International Journal of Endocrinology, 2016
All mammals own two main forms of fat. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue instead of inducing fat ...
Fernando Lizcano, Diana Vargas
doaj   +1 more source

Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition

Molecules, 2020
Human adipose-derived stem cells (hASCs) can be isolated from fat tissue and have attracted interest for their potential therapeutic applications in metabolic disease.
Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Sang Woo Kim   +7 more
doaj   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao   +6 more
wiley   +1 more source

Brown and Beige Fat: Therapeutic Potential in Obesity

Indonesian Biomedical Journal, 2014
BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj   +1 more source

Single‐Nuclei Resolution of Intermuscular Adipose Tissue Indicates an Inflammation‐Associated Cellular Profile in Individuals With Knee Osteoarthritis: Findings From the SOMMA KOA Ancillary Study

Aging Cell, Volume 25, Issue 1, January 2026.
Interrogation of the cellular and transcriptional profile of IMAT in individuals with KOA reveals a pro‐inflammatory phenotype. ABSTRACT Individuals with knee osteoarthritis (KOA) have skeletal muscle changes around the knee joint including reduced quadricep muscle mass and increased intermuscular adipose tissue (IMAT).
Line O. Elingaard‐Larsen, Katie L. Whytock, Adeline Divoux, Cheehoon Ahn, Giovanna Distefano, Bret H. Goodpaster, Paul M. Coen, Jamie N. Justice, Erin E. Kershaw, Nancy E. Lane, Lauren M. Sparks   +10 more
wiley   +1 more source

Epigenetic regulation of beige adipocyte fate by histone methylation

Endocrine Journal, 2019
Adipose tissue harbors plasticity to adapt to environmental thermal changes. While brown adipocyte is a thermogenic cell which produces heat acutely in response to cold stimuli, beige (or brite) adipocyte is an inducible form of thermogenic adipocytes which emerges in the white adipose depots in response to chronic cold exposure.
Kyoko, Tanimura, Tomohiro, Suzuki, Diana, Vargas, Hiroshi, Shibata, Takeshi, Inagaki   +4 more
openaire   +3 more sources

Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes

Molecular Metabolism, 2018
Objective: Thermogenic adipocytes (i.e. brown or brite/beige adipocytes) are able to burn large amounts of lipids and carbohydrates as a result of highly active mitochondria and enhanced uncoupled respiration, due to UCP1 activity.
Didier F. Pisani, Valentin Barquissau, Jean-Claude Chambard, Diane Beuzelin, Rayane A. Ghandour, Maude Giroud, Aline Mairal, Sophie Pagnotta, Saverio Cinti, Dominique Langin, Ez-Zoubir Amri   +10 more
doaj   +1 more source