Results 91 to 100 of about 13,381 (238)

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]

, 2018
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G., Bamshad, David, Bellner, Lars, Favero, Gaia, Grant, Ilana, Lebovics, Edward, Meissner, Aliza, Raffaele, Marco, Rezzani, Rita, Rodella, Luigi F., Sacerdoti, David, Schragenheim, Joseph, Singh, Shailendra P., Vanella, Luca   +13 more
core   +1 more source

Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

MedComm, Volume 6, Issue 11, November 2025.
ASD, a natural plant product screened from small molecule compound library, is an antiobesity agent in mice. ASD promotes BAT thermogenesis to inhibit body weight gain. USP4 was identified and validated as a direct molecular target of ASD. ASD‐induced thermogenesis is modulated by a USP4–PPARγ–UCP1 axis.
Lang Chen, Dong‐Hai Liu, Yu‐Xi Li, Song Yang, Wei‐Hua Jia, Liang Peng, Hong‐Lin Liu, Xing‐Bo Wang, Bing Hu, Yu‐Chen Wang, Calvin Pan, Aldons Jake Lusis, Li‐Hong Liu, Li‐Li Gong   +13 more
wiley   +1 more source

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway

Cell Reports, 2018
Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang, Yan Luo, Chunqing Wang, Xiaofeng Ding, Xin Yang, Dandan Wu, Floyd Silva, Zijiang Yang, Qin Zhou, Lu Wang, Xiaoqing Wang, Jianlin Zhou, Nathan Boyd, Michael Spafford, Mark Burge, Xuexian O. Yang, Meilian Liu   +16 more
doaj   +1 more source

Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis

Frontiers in Physiology, 2021
Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang   +5 more
doaj   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow, A Bartelt, AM Cypess, Ayano Ueno, B Tasic, C Jang, Carlos Henrique Sponton, CB Newgard, CB Newgard, CJ Lynch, CR Green, CT Ferrara, DE Lackey, EG Sustarsic, F Palmieri, Francis C. Szoka, H Ohno, Haruya Takahashi, Hiroko Maki, Homa Majd, Huixia Li, K Ikeda, K Shinoda, Kaori Igarashi, Kazuki Tajima, KC Das, Kenji Ikeda, KH Pietiläinen, KM Huffman, Kyeongkyu Kim, LA Gilbert, Labros Sidossis, M Chondronikola, M Rosell, M Saito, M Wallace, MA Herman, Maki Ohishi, Mami Matsushita, Maria Chondronikola, Masayuki Saito, MD Neinast, Michael T. McManus, Mito Kuroda, Momoko Yoneshiro, Olga R. Ilkayeva, P She, Phillip J. White, PJ White, PJ White, Qiang Wang, Rachana N. Pradhan, Robert W. McGarrah, SH Um, Shingo Kajimura, T Li, T Soga, T Soga, T Yoneshiro, Takamasa Ishikawa, Takeshi Yoneshiro, Teruo Kawada, TJ Wang, Tomoyoshi Soga, Tsuyoshi Goto, V Ouellet, Vanille Juliette Greiner, X Kong, Yann Deleye, Yasuo Oguri, Yong Chen, Zachary Brown, Zhipeng Dai   +72 more
core   +1 more source

Preadipocyte Uncoupling Protein 1 Expression Invoked by Fibroblast Growth Factors Imprints on Post‐Differentiation White and Brown Adipocyte Phenotype

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Primary preadipocytes from inguinal white or interscapular brown fat were treated with paracrine fibroblast growth factors (FGF) 2, 4, 8, or 9. Treatment induced acute Ucp1 expression in preadipocytes, independent of other browning markers. Upon subsequent differentiation, Ucp1 and browning markers were expressed at levels comparable to untreated cells.
Katharina Kuellmer, Carolin Mönch, Wilma Roch, Christine Wurmser, Patricia S. S. Petersen, Hildigunnur Hermannsdóttir, Mersiha Hasic, Brice Emanuelli, Tobias Fromme   +8 more
wiley   +1 more source

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Journal of Experimental & Clinical Cancer Research, 2019
Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer.
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang   +10 more
doaj   +1 more source

Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis

Genes and Diseases, 2022
Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure, ultimately reducing adiposity.
Chun Xing, Duo Jiang, Yang Liu, Qiqun Tang, Haiyan Huang   +4 more
doaj   +1 more source

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes [PDF]

, 2017
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the ...
Arroyo, Vicente, Clària i Enrich, Joan, García-Alonso, Verónica, González Périz, Ana, López Vicario, Cristina, Morán-Salvador, Eva, Párrizas, Marcelina, Rius, Bibiana, Titos Rodríguez, Esther, Werz, Oliver   +9 more
core   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, Volume 15, Issue 10, Page 1643-1657, October 2025.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source