Brd9 antagonism induces beige adipocytes in white adipose tissues and protects against diet-induced obesity. [PDF]
Obesity (Silver Spring)Liu Y, Yin A, Seese K, Fu W, Yin H.
europepmc +2 more sources
Towards a Better Understanding of Beige Adipocyte Plasticity [PDF]
Cells, 2019 Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased ...
Esther Paulo, Biao Wang
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The Common and Distinct Features of Brown and Beige Adipocytes. [PDF]
Trends Endocrinol Metab, 2018 Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morphological and biochemical characteristics, including multilocular lipid droplets and cristae-dense mitochondria ...
Ikeda K, Maretich P, Kajimura S.
europepmc +5 more sources
Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4. [PDF]
, 2017 Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through
Chawla, Ajay +6 more
core +1 more source
Beige Fat Maintenance; Toward a Sustained Metabolic Health
Frontiers in Endocrinology, 2020 Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
doaj +1 more source
Spot-14 and its paralog Spot-14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes. [PDF]
FEBS LettCastro-RodrÃguez LI +3 more
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Irisin Reduces the Metabolic Rate of Beige Adipocytes [PDF]
The 9th Conference of Biochemistry and Physiology of Exercise, 2019 AIM: Irisin is released in the circulation in response to exercise and may increase energy expenditure by stimulating the browning of white adipose tissue through UCP1 upregulation. We aimed to investigate the effects of treatment with human recombinant irisin on the metabolic profile of 3T3-L1 differentiated beige adipocytes.
Maria Vliora +4 more
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TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis [PDF]
Nature Communications, 2020 AbstractIt has been suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense environmental cues such as temperature. Here, we report that subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimulators of beige adipocyte thermogenesis.
Sneha Damal Villivalam +8 more
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Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes [PDF]
Int J Mol SciAdipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases.
Yang S +7 more
europepmc +3 more sources
A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. [PDF]
, 2016 Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its highly recruitable nature and relevance to adult humans, beige adipocytes have gained much ...
Bannai, Makoto +5 more
core +2 more sources