Results 41 to 50 of about 8,288 (202)
Beige Fat Maintenance; Toward a Sustained Metabolic Health
Frontiers in Endocrinology, 2020 Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
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The Common and Distinct Features of Brown and Beige Adipocytes. [PDF]
Trends Endocrinol Metab, 2018 Ikeda K, Maretich P, Kajimura S.
europepmc +3 more sources
Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes [PDF]
Int J Mol SciAdipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases.
Yang S +7 more
europepmc +3 more sources
Towards a Better Understanding of Beige Adipocyte Plasticity [PDF]
Cells, 2019 Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased ...
Esther Paulo, Biao Wang
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ASK1 signalling regulates brown and beige adipocyte function [PDF]
Nature Communications, 2016 AbstractRecent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function.
Kazuki Hattori +6 more
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Nicotine induces a dual effect on the beige-like phenotype in adipocytes [PDF]
Archives of Biological Sciences, 2019 Nicotine, the main component of cigarette smoke, affects white/brown adipocytes. Few studies have concentrated on beige adipocytes. In this study, 3T3-L1 cells were differentiated in the presence of nicotine (25, 50 and 100 μmol/L) during early ...
Chen Hui-Jian +5 more
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Neural control of white, beige and brown adipocytes [PDF]
International Journal of Obesity Supplements, 2015 Reports of brown-like adipocytes in traditionally white adipose tissue (WAT) depots occurred ~30 years ago, but interest in white adipocyte 'browning' only has gained attention more recently. We integrate some of what is known about the sympathetic nervous system (SNS) innervation of WAT and brown adipose tissue (BAT) with the few studies focusing on ...
T J, Bartness, V, Ryu
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Role of small proliferative adipocytes: possible beige cell progenitors [PDF]
Journal of Endocrinology, 2020 Despite extensive investigation, the mechanisms underlying adipogenesis are not fully understood. We previously identified proliferative cells in adipose tissue expressing adipocyte-specific genes, which were named small proliferative adipocytes (SPA). In this study, we investigated the characteristics and roles of SPA in adipose tissue. Epididymal and
Taguchi, Koichiro +9 more
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Advanced Science, 2023 N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li +16 more
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A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
Cell Reports, 2020 Summary: UCP1-dependent thermogenesis is studied to define new strategies to ameliorate obesity and type 2 diabetes; however, animal models are mostly limited to germline mutations of UCP1, which can effect adaptive changes in UCP1-independent pathways ...
Tenagne D. Challa +7 more
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