Results 51 to 60 of about 8,288 (202)

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome

Cell Reports, 2018
Summary: Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making ...
Su Su, Anyonya R. Guntur, Daniel C. Nguyen, Shameem S. Fakory, Chad C. Doucette, Cassandra Leech, Humphrey Lotana, Matthew Kelley, Jaspreet Kohli, Julieta Martino, Sunder Sims-Lucas, Lucy Liaw, Calvin Vary, Clifford J. Rosen, Aaron C. Brown   +14 more
doaj   +1 more source

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

eLife, 2017
Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang, Daniel C Berry, Jonathan M Graff   +2 more
doaj   +1 more source

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function [PDF]

Nature Communications, 2016
AbstractCold temperatures induce formation of beige adipocytes, which convert glucose and fatty acids to heat, and may increase energy expenditure, reduce adiposity and lower blood glucose. This therapeutic potential is unrealized, hindered by a dearth of genetic tools to fate map, track and manipulate beige progenitors and ‘beiging’.
Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff   +2 more
openaire   +3 more sources

Formation of thermogenic adipocytes: What we have learned from pigs

Fundamental Research, 2021
Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise.
Jianguo Zhao, Cong Tao, Chuanhe Chen, Yanfang Wang, Tianxia Liu   +4 more
doaj   +1 more source

Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis

Frontiers in Endocrinology
BackgroundThermogenic beige adipocytes, which dissipate energy as heat, are found in neonates and adults. Recent studies show that neonatal beige adipocytes are highly plastic and contribute to >50% of beige adipocytes in adults.
Raja Gopal Reddy Mooli, Bokai Zhu, Bokai Zhu, Bokai Zhu, Saifur R. Khan, Saifur R. Khan, Saifur R. Khan, Saifur R. Khan, Veerababu Nagati, Kulandaimanuvel Antony Michealraj, Michael J. Jurczak, Sadeesh K. Ramakrishnan, Sadeesh K. Ramakrishnan   +12 more
doaj   +1 more source

Adaptive thermogenesis in adipocytes: Is beige the new brown? [PDF]

Genes & Development, 2013
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat.
Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.   +2 more
openaire   +3 more sources

Mitochondrial RNA stimulates beige adipocyte development in young mice

Nature Metabolism, 2022
Abstract Childhood obesity is a serious public health crisis and a critical factor that determines future obesity prevalence. Signals affecting adipocyte development in early postnatal life have a strong potential to trigger childhood obesity; however, these signals are still poorly understood.
Anh Cuong Hoang, László Sasi-Szabó, Tibor Pál, Tamás Szabó, Victoria Diedrich, Annika Herwig, Kathrin Landgraf, Antje Körner, Tamás Röszer   +8 more
openaire   +3 more sources

Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone

Biology, 2019
While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
doaj   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

PCB126 blocks the thermogenic beiging response of adipocytes

Environmental Science and Pollution Research, 2019
Subcutaneous white adipose tissue is capable of becoming thermogenic in a process that is referred to as "beiging." Beiging is associated with activation of the uncoupling protein, UCP1, and is known to be important for preventing adipose hypertrophy and development of insulin resistance.
Francoise A. Gourronc, Gary H. Perdew, Larry W. Robertson, Aloysius J. Klingelhutz   +3 more
openaire   +3 more sources