Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis [PDF]
Nature Communications, 2023 Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain largely unknown. Here, we show that adipocyte YAP/
Xun Huang +9 more
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Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice [PDF]
Molecular MetabolismObjectives: Creatine kinase B (CKB) is the main isoenzyme driving creatine kinase (CK) activity in classical brown adipocytes. However, the specific CK isoenzyme active in beige adipocytes remains unknown.
Jakub Bunk +6 more
doaj +3 more sources
The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice [PDF]
Nature Communications, 2023 Skeletal muscle and thermogenic adipose tissue are both critical for the maintenance of body temperature in mammals. However, whether these two tissues are interconnected to modulate thermogenesis and metabolic homeostasis in response to thermal stress ...
Lu Jin +25 more
doaj +4 more sources
Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis [PDF]
Advanced Science, 2023 N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li +16 more
doaj +2 more sources
Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity [PDF]
Scientific Reports, 2022 Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%.
Mojgan Nazari +10 more
doaj +2 more sources
IL-25–induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice [PDF]
PLoS Biology, 2021 Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose ...
Lingyi Li +12 more
doaj +3 more sources
Brown and Beige Fat: Therapeutic Potential in Obesity [PDF]
Indonesian Biomedical Journal, 2014 BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj +2 more sources
Nature Communications, 2021 Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti ...
Anna Whitehead +2 more
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Beige Fat Maintenance; Toward a Sustained Metabolic Health [PDF]
Frontiers in Endocrinology, 2020 Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
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Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells [PDF]
Frontiers in Endocrinology, 2015 Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis and metabolism. In response to cold, both classical brown fat and the newly identified beige or brite cells are activated by β-adrenergic ...
Sean Bong Lee +2 more
doaj +2 more sources