Stepping Up Human Beige Fat Cell Production [PDF]
Cell Reports, 2018 Beige fat cells hold significant promise for reducing obesity and metabolic disease. Su et al. (2018) present a robust method to produce human beige adipocytes from pluripotent stem cells via the generation of an expandable intermediary population of ...
Wenli Yang, Patrick Seale
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Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis [PDF]
Nature Communications, 2023 Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain largely unknown. Here, we show that adipocyte YAP/
Xun Huang +9 more
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Beige Fat Maintenance; Toward a Sustained Metabolic Health [PDF]
Frontiers in Endocrinology, 2020 Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy.
Atefeh Rabiee
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The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice [PDF]
Nature Communications, 2023 Skeletal muscle and thermogenic adipose tissue are both critical for the maintenance of body temperature in mammals. However, whether these two tissues are interconnected to modulate thermogenesis and metabolic homeostasis in response to thermal stress ...
Lu Jin +25 more
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FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis [PDF]
Molecular Metabolism, 2021 Objective: Fibroblast growth factor 2 (FGF2) has been reported to play divergent roles in white adipogenic differentiation, however, whether it regulates thermogenesis of fat tissues remains largely unknown.
Haifang Li +11 more
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Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation. [PDF]
Dev Cell, 2020 Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug discovery efforts targeting β-adrenergic signaling have not been fruitful after decades of intensive research. We recently identified a new beige fat regulatory pathway mediated via the nicotinic
Jun H +11 more
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Silver nanoparticles inhibit beige fat function and promote adiposity [PDF]
Molecular Metabolism, 2019 Objective: Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society.
Lishu Yue +15 more
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Post-translational control of beige fat biogenesis by PRDM16 stabilization. [PDF]
Nature, 2022 AbstractCompelling evidence shows that brown and beige adipose tissue are protective against metabolic diseases1,2. PR domain-containing 16 (PRDM16) is a dominant activator of the biogenesis of beige adipocytes by forming a complex with transcriptional and epigenetic factors and is therefore an attractive target for improving metabolic health3–8 ...
Wang Q +14 more
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Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis [PDF]
Advanced Science, 2023 N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li +16 more
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Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity [PDF]
Scientific Reports, 2022 Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%.
Mojgan Nazari +10 more
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