HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16. [PDF]
Endocrinology, 2018 Abstract It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte-specific Hdac3 deletions have presented inconsistent results. In this study, we observed that HDAC3 protein levels were lower in brown fat compared with inguinal subcutaneous adipose tissue, and they decreased in
Liao J +6 more
europepmc +4 more sources
IL-25–induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice [PDF]
PLoS Biology, 2021 Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose ...
Lingyi Li +12 more
doaj +3 more sources
Brown and beige fat: development, function and therapeutic potential [PDF]
Nature Medicine, 2013 Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown adipocytes are located in dedicated depots and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipocytes, also known as beige cells ...
Patrick Seale
exaly +4 more sources
Nature Communications, 2021 Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti ...
Anna Whitehead +2 more
exaly +2 more sources
Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice [PDF]
Molecular MetabolismObjectives: Creatine kinase B (CKB) is the main isoenzyme driving creatine kinase (CK) activity in classical brown adipocytes. However, the specific CK isoenzyme active in beige adipocytes remains unknown.
Jakub Bunk +6 more
doaj +2 more sources
Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]
Nature, 2019 Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
Chen Y +11 more
europepmc +4 more sources
Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells [PDF]
PLoS ONE, 2012 Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes ...
Kosaku Shinoda, Haruya Ohno, Houchun Hu
exaly +2 more sources
m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation. [PDF]
EMBO Rep, 2021 Wu R +9 more
europepmc +3 more sources
CDK6 inhibits white to beige fat transition by suppressing RUNX1. [PDF]
Nat Commun, 2018 Abstract Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation.
Hou X +13 more
europepmc +7 more sources
Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis [PDF]
JCI InsightInterorgan crosstalk via secreted hormones and metabolites is a fundamental aspect of mammalian metabolic physiology. Beyond the highly specialized endocrine cells, peripheral tissues are emerging as an important source of metabolic hormones that ...
Zhimin Chen +5 more
doaj +2 more sources