Adult Epicardial Fat Exhibits Beige Features [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2013 Context: Human epicardial fat has been designated previously as brown-like fat. The supraclavicular fat depot in man has been defined as beige coexistent with classical brown based on its gene expression profile. Objective: The aim of the study was ...
Harold S. Sacks +7 more
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Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis. [PDF]
Biomolecules, 2021 Luo L +5 more
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Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle. [PDF]
Cell MetabVargas-Castillo A +17 more
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(20R)-panaxadiol improves obesity by promoting white fat beigeing [PDF]
Frontiers in Pharmacology, 2023 Introduction: Obesity is an important cause of a range of metabolic diseases. However, the complex mechanisms of obesity and its related diseases make some weight loss methods ineffective or have safety issues. Ginseng, a specialty of Jilin Province in China with both edible and medicinal value, contains mainly ginsenosides and other components.
Yuqian Lv +6 more
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Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone. [PDF]
Biology (Basel), 2019 Phillips KJ.
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Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat [PDF]
Nature Communications, 2016 AbstractCold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout
Takahiro Seki +15 more
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Brown and Beige Fat: Physiological Roles beyond Heat Generation [PDF]
Cell Metabolism, 2015 Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ.
Shingo Kajimura +2 more
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Cellular Origins of Beige Fat Cells Revisited. [PDF]
Diabetes, 2019 Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been a topic of intense discussion ...
Shao M +6 more
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Brown and Beige Fat: Molecular Parts of a Thermogenic Machine [PDF]
Diabetes, 2015 The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways.
Paul Cohen, Bruce M. Spiegelman
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Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis
Genes and Diseases, 2022 Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure, ultimately reducing adiposity.
Chun Xing +4 more
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