Results 21 to 30 of about 30,038 (233)

Zirconyl (IV) Nitrate as Efficient and Reusable Solid Lewis Acid Catalyst for the Synthesis of Benzimidazole Derivatives

Journal of Chemistry, 2013
The present paper introduces a simple and efficient method for the synthesis of substituted benzimidazoles by heterocyclization of different o-phenylenediamines and substituted aromatic carboxylic acid/aldehyde in the presence of zirconyl nitrate as ...
Pratapsinha B. Gorepatil, Yogesh D. Mane, Vilas S. Ingle   +2 more
doaj   +1 more source

Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkyl-substituted benzimidazoles with arenes in the superacid CF3SO3H. NMR and DFT studies of dicationic electrophilic species

Beilstein Journal of Organic Chemistry, 2019
Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkylbenzimidazoles with arenes in the Brønsted superacid TfOH resulted in the formation of the corresponding Friedel–Crafts reaction products, 2-diarylmethyl and 2-arylmethyl-substituted benzimidazoles ...
Dmitry S. Ryabukhin, Alexey N. Turdakov, Natalia S. Soldatova, Mikhail O. Kompanets, Alexander Yu. Ivanov, Irina A. Boyarskaya, Aleksander V. Vasilyev   +6 more
doaj   +1 more source

The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity

CHIMIA, 1973
A number of 2-substituted benzimidazoles has been prepared and the compounds were characterized by their physico-chemical and spectral properties. - Mutagenicity tests with two strains of Salmonella typhimurium revealed that on one hand the mutagenic ...
J.P. Seiler, H. Limacher
doaj   +1 more source

Inhibiting CK2 among Promising Therapeutic Strategies for Gliomas and Several Other Neoplasms

Pharmaceutics, 2022
In gliomas, casein kinase 2 (CK2) plays a dominant role in cell survival and tumour invasiveness and is upregulated in many brain tumours. Among CK2 inhibitors, benzimidazole and isothiourea derivatives hold a dominant position.
Emanuela B. Pucko, Robert P. Ostrowski
doaj   +1 more source

¹³C-NMR Chemical Shifts in 1,3-Benzazoles as a Tautomeric Ratio Criterion

Molecules, 2022
Benzimidazole is an important heterocyclic fragment, present in many biologically active compounds with a great variety of therapeutic purposes. Most of the benzimidazole activities are explained through the existence of 1,3-tautomeric equilibrium.
Efrén V. García-Báez, Itzia I. Padilla-Martínez, Alejandro Cruz, Martha C. Rosales-Hernández   +3 more
doaj   +1 more source

Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy

Pharmaceuticals, 2021
Repurposing of approved non-antitumor drugs represents a promising and affordable strategy that may help to increase the repertoire of effective anticancer drugs.
Rosalba Florio, Simone Carradori, Serena Veschi, Davide Brocco, Teresa Di Genni, Roberto Cirilli, Adriano Casulli, Alessandro Cama, Laura De Lellis   +8 more
doaj   +1 more source

Imidazole as a parent π-conjugated backbone in charge-transfer chromophores

Beilstein Journal of Organic Chemistry, 2012
Research activities in the field of imidazole-derived push–pull systems featuring intramolecular charge transfer (ICT) are reviewed. Design, synthetic pathways, linear and nonlinear optical properties, electrochemistry, structure–property relationships ...
Jiří Kulhánek, Filip Bureš
doaj   +1 more source

Synthesis, Computational Analysis, and Antiproliferative Activity of Novel Benzimidazole Acrylonitriles as Tubulin Polymerization Inhibitors: Part 2

Pharmaceuticals, 2021
We used classical linear and microwave-assisted synthesis methods to prepare novel N-substituted, benzimidazole-derived acrylonitriles with antiproliferative activity against several cancer cells in vitro.
Anja Beč, Lucija Hok, Leentje Persoons, Els Vanstreels, Dirk Daelemans, Robert Vianello, Marijana Hranjec   +6 more
doaj   +1 more source

Boric Acid Catalyzed Convenient Synthesis of Benzimidazoles in Aqueous Media

Journal of Chemistry, 2013
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media. The product is applicable to aryl and heteroaryl aldehydes.
Mohammad Reza Poor Heravi, Marjan Ashori
doaj   +1 more source

La résistance aux benzimidazoles des nématodes gastro-intestinaux des petits ruminants en Gambie et au Sénégal

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1998
Cinquante-cinq troupeaux de petits ruminants en Gambie et au Sénégal ont été examinés en utilisant le test d'inhibition de l'éclosion des œufs et/ou le test de réduction des œufs de nématodes dans les fèces afin de détecter une résistance éventuelle aux
H. Bâ, S. Geerts
doaj   +1 more source