Results 21 to 30 of about 12,670 (192)

α-Chymotrypsin-catalyzed synthesis of 2-substituted benzimidazole through retro-Claisen reaction

Green Chemistry Letters and Reviews, 2018
Benzimidazoles are important components of pharmaceutical compounds owing to their promising bioactivities. The green, safe, and efficient synthesis of benzimidazoles has always been one of the hot topics for chemical workers.
Lian-Sheng Liu, Zong-Bo Xie, Can Zhang, Lei-Han Fu, Hai-Bo Zhu, Zhang-Gao Le   +5 more
doaj   +1 more source

PHARMACOKINETIC PROPERTIES OF A NEW KAPPA-OPIOID ANALGESIC RU-1205 COMPOUND AT A SINGLE PERORAL ADMINISTRATION

Фармация и фармакология (Пятигорск), 2021
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between its ...
A. A. Spasov, L. A. Smirnova, O. Yu. Grechko, N. V. Eliseeva, Yu. V. Lifanova, A. I. Rashchenko, O. N. Zhukovskaya, A. S. Morkovnik, V. A. Anisimova   +8 more
doaj   +1 more source

In-situ Fe electro-oxidation to Improve the Synthesis of Mono and Disubstituted Benzimidazoles

International Journal of Electrochemical Science, 2015
This paper presents an innovative green organic electrosynthesis to prepare benzimidazoles in methanol media at room temperature starting from o-phenylendiammines and benzaldehydes.
I. Monreal, L.J. Torres-Pacheco, M.T. Oropeza-Guzman, I.A. Rivero   +3 more
doaj   +1 more source

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation

Molecules, 2023
Herein, we present the design and synthesis of novel N-substituted benzimidazole-derived Schiff bases, and the evaluation of their antiviral, antibacterial, and antiproliferative activity.
Anja Beč, Maja Cindrić, Leentje Persoons, Mihailo Banjanac, Vedrana Radovanović, Dirk Daelemans, Marijana Hranjec   +6 more
doaj   +1 more source

Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole [PDF]

Journal of the Serbian Chemical Society, 2014
Series of eight novel 5-substituted derivatives of benzimidazole were synthesized by condensation of corresponding diamine with ethyl-4-[4-(2-chlorophenyl)piperazin-1-yl] butanoate in refluxing 4N hydrochloric acid.
Vasić Vesna P., Penjišević Jelena Z., Novaković Irena T., Šukalović Vladimir V., Andrić Deana B., Kostić-Rajačić Slađana V.   +5 more
doaj   +1 more source

Activity of benzimidazoles against Dientamoeba fragilis (Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance

Parasite, 2014
Recently, Dientamoeba fragilis has emerged as a significant and common enteropathogen. The majority of patients with dientamoebiasis present with gastrointestinal complaints and chronic symptoms are common. Numerous studies have successfully demonstrated
Stark Damien, Barratt Joel L.N., Roberts Tamalee, Marriott Deborah, Harkness John T., Ellis John   +5 more
doaj   +1 more source

In Vitro Study of Benzimidazole Derivatives, Tetrahydropyrimidines and Macrocyclic Lactones Therapeutic Efficacy in Dog Hookworms

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine, 2018
The study was conducted using faecal samples from 62 dogs. We tested the ovicidal and larvicidal effects of albendazole (ABZ), mebendazole (MBZ), fenbendazole (FBZ) and flubendazole (FLU) by Egg hatch assay (EHA) and larval development assay (LDA).
Laura CĂTANĂ, Raul CĂTANĂ, Roxana CORA, Ştefan RĂILEANU, Mihai CERNEA   +4 more
doaj   +1 more source

New highlights of the syntheses of pyrrolo[1,2-a]quinoxalin-4-ones

Beilstein Journal of Organic Chemistry, 2014
The one-pot three-component reactions of 1-substituted benzimidazoles with ethyl bromoacetate and electron-deficient alkynes, in 1,2-epoxybutane, gave a variety of pyrrolo[1,2-a]quinoxalin-4-ones and pyrrolo[1,2-a]benzimidazoles.
Emilian Georgescu, Alina Nicolescu, Florentina Georgescu, Florina Teodorescu, Daniela Marinescu, Ana-Maria Macsim, Calin Deleanu   +6 more
doaj   +1 more source

Corrosion protection of mild steel in hydrochloric acid solution through the synergistic of alkylbenzimidazoles and semicarbazide pair – Electroanalytical and computational studies

Egyptian Journal of Petroleum, 2017
Hydrogen bonded interaction and synergistic effect on the corrosion protection properties of alkyl benzimidazoles and semicarbazide pair on mild steel in hydrochloric acid at 303, 308 and 313 K have been studied by polarization, electrochemical impedance
K. Ramya, K.K. Anupama, K.M. Shainy, Abraham Joseph   +3 more
doaj   +1 more source

Design, Synthesis, Biological Evaluation, and Molecular Modeling of 2-Difluoromethylbenzimidazole Derivatives as Potential PI3Kα Inhibitors

Molecules, 2022
PI3Kα is one of the potential targets for novel anticancer drugs. In this study, a series of 2-difluoromethylbenzimidazole derivatives were studied based on the combination of molecular modeling techniques 3D-QSAR, molecular docking, and molecular ...
Xiangcong Wang, Moxuan Zhang, Ranran Zhu, Zhongshan Wu, Fanhong Wu, Zhonghua Wang, Yanyan Yu   +6 more
doaj   +1 more source