Results 41 to 50 of about 1,463 (175)

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Deciphering the influenza neuraminidase inhibitory potential of naturally occurring biflavonoids: An in silico approach

Open Chemistry
Influenza infection poses a significant threat to the existence of humans and animals. Its inhibition by secondary metabolites may proffer a lasting solution to its resistance to available synthetic therapeutic agents.
Faloye Kolade O., Ahmad Shaban, Oyasowo Olubunmi T., Shalom Esther O., Bano Nagmi, Olanudun Esther A., Kelani Tawakalit O., Aliyu Habeeb E., Raza Khalid, Makinde Boluwaji I., Alanzi Abdullah R.   +10 more
doaj   +1 more source

Biflavonoids, Main Constituents from Leaves

Natural Product Communications, 2013
The genus Garcinia is a source of a large variety of organic compounds including biflavonoids, acylphloroglucinols and xanthones mainly, but few data are available about the chemical composition of Cuban species.
Ahmed Al-Shagdari, Adonis Bello Alarcón, Osmany Cuesta-Rubio, Anna Lisa Piccinelli, Luca Rastrelli   +4 more
doaj   +1 more source

Strong and Selective Inhibitory Effects of the Biflavonoid Selamariscina A against CYP2C8 and CYP2C9 Enzyme Activities in Human Liver Microsomes

Pharmaceutics, 2020
Like flavonoids, biflavonoids, dimeric flavonoids, and polyphenolic plant secondary metabolites have antioxidant, antibacterial, antiviral, anti-inflammatory, and anti-cancer properties. However, there is limited data on their effects on cytochrome P450 (
So-Young Park, Phi-Hung Nguyen, Gahyun Kim, Su-Nyeong Jang, Ga-Hyun Lee, Nguyen Minh Phuc, Zhexue Wu, Kwang-Hyeon Liu   +7 more
doaj   +1 more source

Comparative Evaluation of the Cytotoxic Effect of Dysphania ambrosioides Extracts Against Human Breast and Cervical Cancer Cells

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
This study evaluates the geographic influence on the chemical and biological profiles of Dysphania ambrosioides collected from Brazilian and Colombian sources. Following extraction, metabolic fingerprinting via HPLC‐MS reveals distinct phytochemical variations between the geographical origins.
Andres Camilo Moreno Abadia, Lina Marcela Trujillo Chacón, Júlia Biz Willig, Edison Osorio, Diogo André Pilger, Miriam Anders Apel, Simone Cristina Baggio Gnoatto   +6 more
wiley   +1 more source

Green Synthesis of AuNPs Using Red Propolis: Physicochemical Characterization and Selective Biological Cell Response

ChemistrySelect, Volume 11, Issue 25, 3 July 2026.
Purified Red Propolis; Physicochemical characterization; Purified RP; HAuCl4; AuNPs; Characterization of AuNPs; Cytotoxic activity of AuNPs. ABSTRACT Gold nanoparticles (AuNPs) have attracted considerable interest for biomedical applications due to their biocompatibility, tunable physicochemical properties, and potential for surface functionalization ...
Marina Della Giustina, Jordana Bortoluz, Raquel Checca, Daniel R. Louzada, Alessandro Ajó, Rubem L. Sommer, Luisa De Cola, Marcelo Giovanela, Janaina da Silva Crespo, Mariana Roesch‐Ely   +9 more
wiley   +1 more source

Chemical Profiling, Pharmacological Activities, and Toxicity Assessment of Juniperus phoenicea sp. turbinata L. Extract: Integrated In Vitro, In Vivo, and In Silico Insights

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Hydroethanolic leaf and fruit extracts of Juniperus phoenicea showed high phenolic content, dominated by ferulic acid. Both extracts were non‐toxic and exhibited strong anti‐inflammatory, analgesic, antioxidant, and antimicrobial activities. Molecular docking confirmed stable binding to key inflammatory and microbial targets, supporting its ...
Tarik Chelouati, Soufyane Lafraxo, Amira Metouekel, Mostafa Messkini, Salah‐eddine Chebaibi, Abdelfattah E. L. Moussaoui, Azeddin El Barnossi, Esmael M. Alyami, Ohoud A. Alghamdi, Yousef A. Bin Jardan, Gehan M. Elossaily, Musaab Dauelbait, Musa A. Said, Ahmed Samir Benjelloun   +13 more
wiley   +1 more source

Influence of Air Drying, Freeze Drying and Oven Drying on the Biflavone Content in Yellow Ginkgo (Ginkgo biloba L.) Leaves

Applied Sciences
Drying herbs is a crucial method for stabilizing and preserving their essential properties and bioactive compounds. Although freeze drying is the preferred method for most herbs, it is expensive due to high energy consumption and operating costs ...
Iva Jurčević Šangut, Lana Pavličević, Dunja Šamec   +2 more
doaj   +1 more source

Amentoflavone, a Preferentially TGF‐β Receptor 1 Inhibitor, Alleviates Cardiac Remodeling and Dysfunction Through Modulating the TGF‐β/Smad and MAPK Signaling Pathways

Phytotherapy Research, Volume 40, Issue 5, Page 2380-2396, May 2026.
Amentoflavone, a preferentially TGF‐ββ receptor 1 inhibitor, attenuates transverse aortic constriction (TAC)‐triggered cardiac hypertrophy, fibrosis, and dysfunction by suppressing downstream Smad and MAPK signaling cascades in cardiomyocytes and cardiac fibroblasts.
Jiangjiao Wu, Chengcheng Zhao, Xiaoping Li, Xinyi Guo, Wenjie Tan, Lu Zhou, Ye Zhang, Jianli Zhang, Shuo Zheng, Chunyu Zeng, Gengze Wu   +10 more
wiley   +1 more source

Flavonoids and Other Compounds from <em>Ouratea ferruginea </em>(Ochnaceae) as Anticancer and Chemopreventive Agents

Molecules, 2012
The chemical study of the extracts from leaves and stems of <em>Ouratea ferruginea</em> allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β ...
Queli C. Fidelis, Rosane N. Castro, Giselle M. S. P. Guilhon, Silvane T. Rodrigues, Cristiane M. C. de Salles, João B. de Salles, Mario G. de Carvalho   +6 more
doaj   +1 more source