Results 91 to 100 of about 14,906 (242)

Biglycan gene connects metabolic dysfunction with brain disorder

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Dietary fructose is a major contributor to the epidemic of diabetes and obesity, and it is an excellent model to study metabolic syndrome. Based on previous studies that Bgn gene occupies a central position in a network of genes in the brain in response to fructose consumption, we assessed the capacity of Bgn to modulate the action of fructose on brain
Ying, Zhe, Byun, Hyae Ran, Meng, Qingying, Noble, Emily, Zhang, Guanglin, Yang, Xia, Gomez-Pinilla, Fernando   +6 more
openaire   +5 more sources

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong, Zhen Guo, Yu‐Lan Ma, Ming‐Yu Wang, Hai‐Yang Ni, Pan Wang, Wen‐Jun Qiu, En‐Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi‐Zhu Tang   +11 more
wiley   +1 more source

Gene expression and matrix turnover in overused and damaged tendons [PDF]

, 2005
Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the
Abbaszade I, Akeson WH, Alfredson H, Amiel D, Archambault J, Astrom M, Bank RA, Banyard J, Benjamin M., Berenson MC, Boot-Handford RP, Brown PD., Cal S, Caterson B, Cawston TE, Cawston TE., Clark IM, Colige A, Colige A, Collins-Racie LA, Corps AN, Corps AN, Curwin SL, Dalton S, Dickinson SC, Eriksen HA, Everts V, Fernandes RJ, Fitzgerald J, Flannery CR, G. P. Riley, Gao G, Gelberman RH, Gillard GC, Gotoh M, Hannafin JA., Hardingham TE, Hashimoto T, Heinemeier K, Ireland D, Jarvinen M, Jozsa L, Jozsa L, Kannus P, Kannus P., Kannus P., Kashiwagi M, Kashiwagi M, Kaushal GP, Kjaer M, Koch M, Koch M, Koshy PJ, Koskinen SO, Kuno K, Langberg H, Langberg H, Langberg H, Leadbetter WB., Lehto M, McCawley LJ, McNeilly CM, Murphy G, Myllyharju J, Nagase H., Pace JM, Patterson-Kane JC, Pierfitte C, Rees SG, Riley G., Riley GP, Riley GP, Riley GP, Riley GP, Riley GP, Riley GP., Samiric T, Samiric T, Sandy JD, Sandy JD, Sandy JD, Sato K, Smith RK, Smith RK, Somerville RP, Tipton CM, Tortorella MD, Tortorella MD, Tsuzaki M, Vankemmelbeke MN, Vogel KG, Waggett AD, Wang P, Woo SLY, Woo SLY, Woo SLY, Yasuda K, Yoshihara Y   +97 more
core   +1 more source

Targeting the Glial Scar: Biomaterial and Drug‐Based Strategies for Modulation In Vitro

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 12, December 2025.
Human cell‐based in vitro glial‐scar model used to evaluate therapeutics and biomaterials. ABSTRACT Glial scarring creates a significant obstacle for axonal regeneration in the central nervous system after injury and represents one of the main hurdles for neural microelectrode development.
Luise Schlotterose, Duygu Dengiz, Meryem G. Ersahin, Eckhard Quandt, Karsten Steffens, Dennis Schade, Francois Cossais, Ralph Lucius, Kirsten Hattermann   +8 more
wiley   +1 more source

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review [PDF]

European Cells & Materials, 2017
To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury ...
O Evrova, J Buschmann
doaj   +1 more source

Small leucine rich proteoglycans are differently distributed in normal and pathological endometrium [PDF]

, 2015
BACKGROUND: During the woman's fertile period, the non-pregnant uterus is subject to constant cyclic changes. The complex mechanisms that control the balance among proliferation, differentiation, cell death and the structural remodeling of the ...
Boccia, Olga, Castaldi, Maria A., Cobellis, Luigi, DE FALCO, MARIA, De Luca, Antonio, Lucariello, Angela, Perna, Angelica, Sellitto, Carmine, Trabucco, Elisabetta   +8 more
core  

Characterizing Microstructural and Mechanical Properties of Dancer Achilles Tendon Using Ultrashort Echo Time MRI and Shear Wave Elastography Ultrasound

Journal of Orthopaedic Research, Volume 43, Issue 12, Page 2093-2101, December 2025.
ABSTRACT Previous observations of multi‐echo ultrashort echo time (UTE) magnetic resonance imaging (MRI) decay data from the Achilles tendon (AT) report an off‐resonance non‐water signal associated with non‐collagenous extracellular matrix (ECM) constituents.
Anna M. Horner, Felix M. Gonzalez, Courtney N. Gleason, Amanda Blackmon, Emma Faulkner, Damian Dyckman, Monica B. Umpierrez, Philip K.‐W. Wong, Vahid Khalilzad Sharghi, Pan Su, David A. Reiter   +10 more
wiley   +1 more source

The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho‐Anatomical Studies: A Historical Perspective

JOR SPINE, Volume 8, Issue 4, December 2025.
The ovine annular rim‐lesion model of intervertebral disc degeneration of Osti and colleagues (1990) has evolved into a sophisticated mechanical destabilization large animal model of intervertebral disc degeneration over its 35 year history offering diverse musculoskeletal multi‐disciplinary investigations into the multifunctional complexity of this ...
O. Osti, C. B. Little, J. Melrose
wiley   +1 more source

Cellular and molecular pathology of age-related macular degeneration: Potential role for proteoglycans [PDF]

, 2016
Age-related macular degeneration (AMD) is a retinal disease evident after the age of 50 that damages the macula in the centre of retina. It leads to a loss of central vision with retained peripheral vision but eventual blindness occurs in many cases. The
Algwairi, O, Little AM, P, Osman, N, Thach, L, Zheng, W   +4 more
core   +2 more sources

Associations of Adipocyte-derived Versican and Macrophage-derived Biglycan with Body Adipose Tissue and Hepatosteatosis in Obese Children

JCRPE
INTRODUCTION: In animal models of obesity, adipocyte-derived versican, and macrophage-derived biglycan play a crucial role in mediating adipose tissue inflammation.
Reyhan Deveci Sevim, Mustafa Gök, Özge Çevik, Ömer Erdoğan, Sebla Güneş, Tolga Ünüvar, Ahmet Anık   +6 more
doaj   +1 more source