Results 41 to 50 of about 6,730 (161)

Adipose tissue biglycan as a potential anti-inflammatory target of sodium salicylate in mice fed a high fat diet

Journal of Inflammation, 2012
Background Inflammation in adipose tissue (AT) during obesity causes impaired AT function. Although multiple extracellular matrix (ECM) proteins are expressed in AT their potential role in adipose tissue inflammation is unclear.
Adapala Venkata J, Ward Meliza, Ajuwon Kolapo M   +2 more
doaj   +1 more source

Biglycan gene expression in UVR‐exposed rabbit corneas [PDF]

Acta Ophthalmologica Scandinavica, 2004
Abstract.Purpose: It is known that stromal proteoglycans play an important role in the hydration and transparency of the mammalian cornea. Proteoglycans have been described as a pathological deposit in climatic proteoglycan stromal keratopathy, which is associated with chronic ultraviolet radiation (UVR) exposure.
Alexander, Podskochy, Marina, Koulikovska, Per, Fagerholm, Ingeborg, van der Ploeg   +3 more
openaire   +2 more sources

Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction [PDF]

Circulation, 2008
Background— After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function.
Westermann, D., Mersmann, J., Melchior, A., Freudenberger, T., Petrik, C., Schaefer, L., Lüllmann-Rauch, R., Lettau, O., Jacoby, C., Schrader, J., Brand-Herrman, S.M., Young, M.F., Schultheiss, H.P., Levkau, Bodo, Baba, Hideo Andreas, Unger, T., Zacharowski, K., Tschöpe, C., Fischer, J.W., Brand-Herrmann, S.-M.   +19 more
openaire   +3 more sources

Tumour necrosis factor‐α interacts with biglycan and decorin [PDF]

FEBS Letters, 2002
Several interactions of cytokines with extracellular matrix molecules are mediated by proteoglycans, such as biglycan and decorin. Using surface plasmon resonance, we show for the first time that tumour necrosis factor‐α (TNF‐α) binds to both biglycan and decorin with K ds of 0.81 μM and 1.23 μM respectively, a binding that was confirmed by Scatchard ...
Tufvesson, Ellen, Westergren-Thorsson, Gunilla   +1 more
openaire   +2 more sources

Biglycan and atherosclerosis: Lessons from high cardiovascular risk conditions [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2020
Atherosclerosis (ATH) is a chronic, dynamic, evolutive process involving morphological and structural subversion of artery walls, leading to the formation of atherosclerotic plaques. ATH generally initiates during the childhood, occurring as a result of a number of changes in the intima tunica and in the media of arteries.
Scuruchi M., Poti F., Rodriguez-Carrio J., Campo G. M., Mandraffino G.   +4 more
openaire   +5 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr−/− mice1

Journal of Lipid Research, 2013
Angiotensin II (angII) accelerates atherosclerosis, but the mechanisms are not fully understood. The aim of this study was to determine whether TGFβ is required for angII-induced atherosclerosis.
Tao Tang, Patricia G. Wilson, Joel C. Thompson, Christina Nelson, Meghan H. Yoder, Lisa R. Tannock   +5 more
doaj   +1 more source

Different Usage of the Glycosaminoglycan Attachment Sites of Biglycan [PDF]

Journal of Biological Chemistry, 2001
Biglycan is a member of the small leucine-rich proteoglycan family. Its core protein comprises two chondroitin/dermatan sulfate attachment sites on serine 42 and serine 47, respectively, which are the fifth and tenth amino acid residues, respectively, after removal of the prepro peptide. Because the regulation of glycosaminoglycan chain assembly is not
H, Kresse, D G, Seidler, M, Muller, E, Breuer, H, Hausser, P J, Roughley, E, Schonherr   +6 more
openaire   +2 more sources

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, EarlyView.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source