Results 41 to 50 of about 14,906 (242)
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]
, 2017 Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR +5 more
core +2 more sources
Biglycan Deficiency Interferes With Ovariectomy-Induced Bone Loss [PDF]
Journal of Bone and Mineral Research, 2003 Abstract Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.
Nielsen, Karina L +7 more
openaire +4 more sources
Cell Reports, 2020 Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han +15 more
doaj +1 more source
Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells [PDF]
, 2007 Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis. Studies have established a direct role for nitric oxide (NO) in the regulation of gene expression in mesangial cells.
Banas B. +11 more
core +1 more source
Borrelia burgdorferi Infection in Biglycan Knockout Mice
The Journal of Infectious Diseases, 2019 Borrelia burgdorferi sensu lato spirochetes (Borrelia) causing Lyme borreliosis are able to disseminate from the initial entry site to distant organs in the host. Outer-surface adhesins are crucial in the bacterial dissemination and adhesion to various tissues.
Pietikäinen Annukka +7 more
openaire +4 more sources
Journal of Lipid Research, 2002 Retention of apolipoprotein (apo)B and apoE-containing lipoproteins by extracellular vascular proteoglycans is critical in atherogenesis. Moreover, high circulating apoC-III levels are associated with increased atherosclerosis risk.
Katherine Olin-Lewis +6 more
doaj +1 more source
Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer
Thoracic Cancer, 2021 Objectives In lung cancer, surgery remains the most curative treatment and limited resection is beneficial for patients with low cardiopulmonary function and low malignancy tumors.
Hirofumi Morimoto +9 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2021 Hedgehog (Hh) signalling plays essential roles in regulating embryonic development and contributes to tumour initiation, growth and progression in multiple cancers.
Zeng Shaopeng +8 more
doaj +1 more source
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans. [PDF]
, 2010 The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease. They are now being recognized as key signaling molecules with an expanding repertoire of molecular interactions affecting not only
Iozzo, Renato V., Schaefer, Liliana
core +2 more sources
Journal of Lipid Research, 2017 Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan.
Patricia G. Wilson +4 more
doaj +1 more source