Results 81 to 90 of about 6,730 (161)

Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong, Teun B. Petersen, Sabrina Abou Kamar, Navin Suthahar, Nick van Boven, K. Martijn Akkerhuis, Peter J. van der Spek, Peter D. Katsikis, Rudolf A. de Boer, Victor A. W. M. Umans, Eric Boersma, Folkert W. Asselbergs, Jasper J. Brugts, Sing‐Chien Yap, Isabella Kardys   +14 more
wiley   +1 more source

Differential roles for small leucine-rich proteoglycans in bone formation

European Cells & Materials, 2003
This paper reviews our current state of knowledge of the roles the small leucine-rich proteoglycans (SLRPs) play in the formation of connective tissue and mineralised tissue matrices.
Waddington R. J., Roberts H. C., Sugars R. V., Schonherr E.   +3 more
doaj  

Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development1

Journal of Lipid Research, 2008
Angiotensin II (angII) is known to promote atherosclerosis; however, the mechanisms involved are not fully understood. To determine whether angII stimulates proteoglycan production and LDL retention, LDL receptor-deficient mice were infused with angII (1,
Fei Huang, Joel C. Thompson, Patricia G. Wilson, Hnin H. Aung, John C. Rutledge, Lisa R. Tannock   +5 more
doaj   +1 more source

Investigation of Inflammation and Autophagy due to Biglycan-mediated TLR2/4 Signaling in Oral Lichen Planus Tissues [PDF]

Forbes Tıp Dergisi
Objective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis.
Özlem Ceren GÜNİZİ, Hüseyin GÜNİZİ, Hamiyet ECİROĞLU, Fatma YILDIZ   +3 more
doaj   +1 more source

Polymorphism of BGN gene (g.77807325 G>C) and its association with fatty acid and carcass characteristics of Indonesian meat lamb

Journal of the Indonesian Tropical Animal Agriculture
Fatty acid content and carcass characteristics are two meat quality traits consumers choose to ob tain healthy and high-quality lamb. Genetic improvement of fatty acid content and carcass characteris tics in sheep is important to increase the public ...
M. F. Amin, C. Sumantri, I. I. Arief, A. Jayanegara, K. Listyarini, R. S. Harahap, A. Gunawan   +6 more
doaj   +1 more source

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells

OncoImmunology, 2018
The extracellular matrix protein biglycan (BGN) has oncogenic or tumor suppressive potential depending on the cellular origin. HER-2/neu overexpression in murine fibroblasts and human model systems is inversely correlated with BGN expression.
Karthikeyan Subbarayan, Sandra Leisz, Claudia Wickenhauser, Daniel Bethmann, Chiara Massa, André Steven, Barbara Seliger   +6 more
doaj   +1 more source

Immunohistochemical expression of biglycan and decorin in the pulp tissue of human primary teeth during resorption

Brazilian Oral Research, 2013
Primary teeth are interesting models that can be used to study physiological and pathological processes involving cells and extracellular matrices in hard and soft tissues.
Monique Saveriano De Benedetto, Filipe Modolo Siqueira, Marcelo Betti Mascaro, Vera Cavalcanti Araujo, Marcelo Jose Strazzeri Bonecker   +4 more
doaj   +1 more source

Biglycan modulates angiogenesis and bone formation during fracture healing

Matrix Biology, 2014
Matrix proteoglycans such as biglycan (Bgn) dominate skeletal tissue and yet its exact role in regulating bone function is still unclear. In this paper we describe the potential role of (Bgn) in the fracture healing process. We hypothesized that Bgn could regulate fracture healing because of previous work showing that it can affect normal bone ...
Berendsen, Agnes D., Pinnow, Emily L., Maeda, Azusa, Brown, Aaron C., McCartney-Francis, Nancy, Kram, Vardit, Owens, Rick T., Robey, Pamela G., Holmbeck, Kenn, de Castro, Luis F., Kilts, Tina M., Young, Marian F.   +11 more
openaire   +2 more sources

Identification of New, Translatable ProtectomiRs against Myocardial Ischemia/Reperfusion Injury and Oxidative Stress: The Role of MMP/Biglycan Signaling Pathways

Antioxidants
Introduction: Ischemic conditionings (ICon) were intensively investigated and several protective signaling pathways were identified. Previously, we have shown the role of matrix metalloproteinases (MMP) in myocardial ischemia/reperfusion injury (MIRI ...
Tamara Szabados, Arnold Molnár, Éva Kenyeres, Kamilla Gömöri, Judit Pipis, Bence Pósa, András Makkos, Bence Ágg, Zoltán Giricz, Péter Ferdinandy, Anikó Görbe, Péter Bencsik   +11 more
doaj   +1 more source

Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL1

Journal of Lipid Research, 2002
Atherosclerosis is the main cause of morbidity and mortality in diabetes, yet the underlying mechanisms remain unclear. Retention of atherogenic lipoproteins by vascular proteoglycans is thought to play a key role in the development of atherosclerotic ...
Lisa R. Tannock, Peter J. Little, Thomas N. Wight, Alan Chait   +3 more
doaj   +1 more source