Results 81 to 90 of about 14,906 (242)
Increased atherosclerosis in mice with increased vascular biglycan content [PDF]
Atherosclerosis, 2014 The response to retention hypothesis of atherogenesis proposes that atherosclerosis is initiated via the retention of atherogenic lipoproteins by vascular proteoglycans. Co-localization studies suggest that of all the vascular proteoglycans, biglycan is the one most closely co-localized with LDL.
Joel C, Thompson +4 more
openaire +2 more sources
Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker +5 more
wiley +1 more source
Coupling of small leucine-rich proteoglycans to hypoxic survival of a progenitor cell-like subpopulation in Rhesus Macaque intervertebral disc [PDF]
, 2013 Degeneration of the intervertebral disc (IVD) is a major spinal disorder that associates with neck and back pain. Recent studies of clinical samples and animal models for IVD degeneration have identified cells with multi-potency in the IVD.
Chan, D +6 more
core +1 more source
The functional network of biglycan: A new frontier in tumor progression [PDF]
, 2023 Li Yu +3 more
openalex +1 more source
Journal of Orthopaedic Research, Volume 44, Issue 1, January 2026.ABSTRACT Remodeling of the extracellular matrix (ECM) is required for the proper healing, strengthening, and maintenance of tendon tissue. There are well‐documented sex differences in tendon injury rates and healing outcomes, often attributed to either innate differences in tissue structure and resident cell signaling or the influence of sex hormones ...
Allison M. Sander, Brianne K. Connizzo
wiley +1 more source
Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy
OncoImmunology, 2023 Myelodysplastic syndromes (MDS) and their progression to secondary acute myeloid leukemia (sAML) are associated with an altered protein expression including extracellular matrix (ECM) components thereby promoting an inflammatory environment.
Christoforos K. Vaxevanis +8 more
doaj +1 more source
Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure
PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong +14 more
wiley +1 more source
Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate. [PDF]
, 2019 Collagen remodeling occurs in many prostate pathologies; however, the underlying structural architecture in both normal and diseased prostatic tissues is largely unexplored.
Bushman, Wade A. +5 more
core +1 more source
Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation [PDF]
, 2014 Proteoglycans are associated with the initiation of atherosclerosis due to their binding of apolipoproteins on lipid particles leading to retention in the vessel wall.
Getachew, R +6 more
core +1 more source
The FEBS Journal, Volume 293, Issue 1, Page 42-70, January 2026.This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leanna Leverton +4 more
wiley +1 more source