Results 1 to 10 of about 57,598 (139)

Bile salt evolution

Journal of Lipid Research, 1967
Viewed against the background of known or supposed biosynthetic pathways for cholic and chenodeoxycholic acids in man and laboratory animals, the chemical nature of bile salts in more primitive animals clearly indicates that evolution from C27, 5α ...
G.A.D. Haslewood
doaj   +3 more sources

Holistic analysis of lysine acetylation in aquaculture pathogenic bacteria Vibrio alginolyticus under bile salt stress [PDF]

Frontiers in Veterinary Science, 2023
Lysine acetylation modification is a dynamic and reversible post-translational modification, which plays an important role in the metabolism and pathogenicity of pathogenic bacteria.
Xing Xiao, Xing Xiao, Wanxin Li, Yanfang Pan, Yanfang Pan, Junlin Wang, Junlin Wang, Zhiqing Wei, Zhiqing Wei, Shi Wang, Shi Wang, Na Wang, Jichang Jian, Jichang Jian, Huanying Pang, Huanying Pang   +15 more
doaj   +2 more sources

Bile salt signaling and bile salt-based therapies in cardiometabolic disease. [PDF]

Clin Sci (Lond)
Abstract Bile salts have an established role in the emulsification and intestinal absorption of dietary lipids, and their homeostasis is tightly controlled by various transporters and regulators in the enterohepatic circulation. Notably, emerging evidence points toward bile salts as major modulators of cardiometabolic disease (CMD), an ...
Groenen CCJ, Nguyen TA, Paulusma CC, van de Graaf SFJ.   +3 more
europepmc   +3 more sources

The acidic microenvironment in the perisinusoidal space critically determines bile salt-induced activation of hepatic stellate cells [PDF]

Communications Biology
Cholestatic liver diseases, accompanied by the hepatic accumulation of bile salts, frequently lead to liver fibrosis, while underlying profibrogenic mechanisms remain incompletely understood.
Jingguo Li, Shun Yao, Sebastian Zimny, Dennis Koob, Hai Jin, Ralf Wimmer, Gerald Denk, Biguang Tuo, Simon Hohenester   +8 more
doaj   +2 more sources

Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1−/− Ldlr−/− mice [PDF]

Journal of Lipid Research
Bile salts can strongly influence energy metabolism through systemic signaling, which can be enhanced by inhibiting the hepatic bile salt transporter Na+ taurocholate cotransporting polypeptide (NTCP), thereby delaying hepatic reuptake of bile salts to ...
Begoña Porteiro, Reinout L.P. Roscam Abbing, Wietse In het Panhuis, Dirk R. de Waart, Suzanne Duijst, Isabelle Bolt, Esther W. Vogels, Johannes H.M. Levels, Laura A. Bosmans, Winnie G. Vos, Ronald P.J. Oude Elferink, Esther Lutgens, Stan F.J. van de Graaf   +12 more
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Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice [PDF]

JHEP Reports
Background & Aims: Intestine-restricted inhibitors of the apical sodium-dependent bile acid transporter (ASBT, or ileal bile acid transporter) are approved as treatment for several inheritable forms of cholestasis but are also associated with ...
Roni F. Kunst, Isabelle Bolt, Rychon D.J. van Dasselaar, Bart A. Nijmeijer, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +6 more
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Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs [PDF]

Communications Biology
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C.
Rongji Sum, Sylvester Jian Ming Lim, Ajitha Sundaresan, Sudipta Samanta, Muthukaruppan Swaminathan, Wayne Low, Madhumitha Ayyappan, Ting Wei Lim, Marvin Dragon Choo, Gabriel Junming Huang, Ian Cheong   +10 more
doaj   +2 more sources

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

JHEP Reports, 2022
Background & Aims: Non-absorbable inhibitors of the apical sodium-dependent bile acid transporter (ASBT; also called ileal bile acid transporter [IBAT]) are recently approved or in clinical development for multiple cholestatic liver disorders and ...
Roni F. Kunst, Dirk R. de Waart, Frank Wolters, Suzanne Duijst, Esther W. Vogels, Isabelle Bolt, Joanne Verheij, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +9 more
doaj   +1 more source

Comparative Genomic Analysis Determines the Functional Genes Related to Bile Salt Resistance in Lactobacillus salivarius

Microorganisms, 2021
Lactobacillus salivarius has drawn attention because of its promising probiotic functions. Tolerance to the gastrointestinal tract condition is crucial for orally administrated probiotics to exert their functions.
Qiqi Pan, Xudan Shen, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai   +7 more
doaj   +1 more source

New Kids on the Block: Bile Salt Conjugates of Microbial Origin

Metabolites, 2022
Biotransformation of host bile salts by gut microbes results in generation of secondary bile salt species that have biological and physicochemical properties that are distinct from the parent compounds.
Ümran Ay, Martin Leníček, Arno Classen, Steven W. M. Olde Damink, Carsten Bolm, Frank G. Schaap   +5 more
doaj   +1 more source