Results 21 to 30 of about 57,618 (156)

Cholesterol attenuates cytoprotective effects of phosphatidylcholine against bile salts

Scientific Reports, 2017
Bile salts have potent detergent properties and damaging effects on cell membranes, leading to liver injury. However, the molecular mechanisms for the protection of hepatocytes against bile salts are not fully understood.
Yoshito Ikeda, Shin-ya Morita, Tomohiro Terada   +2 more
doaj   +1 more source

Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites

BMC Evolutionary Biology, 2010
Background Bile salts are the major end-metabolites of cholesterol and are also important in lipid and protein digestion and in influencing the intestinal microflora.
Hofmann Alan F, Vidal Nicolas, Hagey Lee R, Krasowski Matthew D   +3 more
doaj   +1 more source

Interactions of cationic bile salt derivatives with the ileal bile salt transport system.

Journal of Lipid Research, 1975
Previous structure-activity studies of the active ileal bile salt transport system have demonstrated that a single negative charge on the side chain is essential for active transport. Furthermore, mutual inhibition studies between different pairs of bile
A Firpi, J T Walker, L Lack
doaj   +1 more source

The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors

Canadian Journal of Gastroenterology, 2003
The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
doaj   +1 more source

Effect of bile salts on hepatic phosphatidylcholine synthesis and transport into rat bile

Journal of Lipid Research, 1972
The effect of transport of micelle-forming and non-micelle-forming conjugated bile salts on phosphatidylcholine synthesis and transport into bile was studied in the ex vivo perfused rat liver.
David L. Young, Kenneth C. Hanson
doaj   +1 more source

Identification of Novel Bile Salt-Tolerant Genes in Lactobacillus Using Comparative Genomics and Its Application in the Rapid Screening of Tolerant Strains

Microorganisms, 2022
Under bile salt treatment, strains display significant differences in their tolerance ability, suggesting the existence of diverse resistance mechanisms in Lactobacillus; however, the genes involved in this protective process are not fully understood. In
Chunfei Chen, Leilei Yu, Fengwei Tian, Jianxin Zhao, Qixiao Zhai   +4 more
doaj   +1 more source

Bile salt hydrolase catalyses formation of amine-conjugated bile acids. [PDF]

Nature
Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD.   +30 more
europepmc   +2 more sources

Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: pathophysiology of biliary lipid secretion1

Journal of Lipid Research, 1999
The inbred C57L strain but not the AKR strain of mice carry Lith genes that determine cholesterol gallstone susceptibility. When C57L mice are fed a lithogenic diet containing 15% fat, 1% cholesterol, and 0.5% cholic acid, gallbladder bile displays rapid
David Q-H. Wang, Frank Lammert, Beverly Paigen, Martin C. Carey   +3 more
doaj   +1 more source

Contribution of vesicular and micellar carriers to cholesterol transport in human bile.

Journal of Lipid Research, 1985
A nonmicellar, bile salt-independent mode of cholesterol transport in human bile involving phospholipid vesicles was recently reported by our group. In the present study, we have investigated the relative contribution of the phospholipid vesicles and ...
G J Sömjen, T Gilat
doaj   +1 more source

Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection

Journal of Lipid Research, 1996
Tauroursodeoxycholate (TUDC), a relatively hydrophilic bile salt, reduces disruption of cholesterol-rich membranes by more hydrophobic bile salts such as taurocholate (TC), taurochenodeoxycholate (TCDC), or taurodeoxycholate (TDC).
D M Heuman, R S Bajaj, Q Lin
doaj   +1 more source