The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes [PDF]
JM Rosen+3 more
openalex +1 more source
Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant
ABSTRACT The complexity of mechanical and biological processes in filamentous fungal fermentation remains a major obstacle to improving product yield. We previously demonstrated that the AGΔ‐GAGΔ strain of Aspergillus oryzae, lacking both α‐1,3‐glucan (AG) and galactosaminogalactan (GAG), had improved hyphal dispersion, reduced culture viscosity, and ...
Shunya Susukida+7 more
wiley +1 more source
The manufacture of AAV for gene therapy applications using a closed, semi-automated hollow-fiber bioreactor. [PDF]
Soula A+17 more
europepmc +1 more source
A study on the convergence of observer-based kinetics estimators in stirred tank bioreactors [PDF]
Rui Oliveira+3 more
openalex +1 more source
A Setup for Automatic Raman Measurements in High‐Throughput Experimentation
Record Raman spectra in High‐Throughput Bioprocess Development. Measure eight samples of 50μL $50\,\mathrm{\mu L}$ fully automated. ABSTRACT High‐throughput (HT) experimentation is transforming biotechnology by enabling systematic exploration of complex multi‐dimensional experimental conditions.
Christoph Lange+8 more
wiley +1 more source
Process development for production of non-originator NISTmAb from CHO and NS0 cell lines. [PDF]
Fratz-Berilla EJ+4 more
europepmc +1 more source
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer+7 more
wiley +1 more source
Enhancing the maturity of <i>in vitro</i> engineered cartilage from Wharton's jelly-derived photo-crosslinked hydrogel using dynamic bioreactors and its <i>in vivo</i> outcomes in animal models. [PDF]
Wei C+5 more
europepmc +1 more source