Results 181 to 190 of about 182,780 (336)

Scenario-based techno-economic analysis of pumped denitrification bioreactors

Lindsey M. Hartfiel, Carolina Díaz-García, Laura E. Christianson, Michelle L. Soupir   +3 more
openalex   +1 more source

A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho, Ana Cruz, Cees Haringa, Marcel Ottens, Marieke Klijn   +4 more
wiley   +1 more source

Upscaling: efficient generation of human lung organoids from induced pluripotent stem cells using a stirring bioreactor. [PDF]

Front Bioeng Biotechnol
Budeus B, Kroepel C, Sevindik ZF, Buttler LF, Klein D.   +4 more
europepmc   +1 more source

Bioreactors [PDF]

Nature Biotechnology, 1995
openaire   +1 more source

Effect of organic load and nutrient ratio on the operation stability of the moving bed bioreactor for kraft mill wastewater treatment and the incidence of polyhydroxyalkanoate biosynthesis

, 2012
Guillermo Pozo, Cristina Alejandra Villamar, Mercedes Martı́nez, Gladys Vidal   +3 more
openalex   +2 more sources

Lab‐Scale Continuous Biomanufacturing: A Tool for Process Development With Adaptive Strategies for Capture and Virus Inactivation

Biotechnology and Bioengineering, EarlyView.
Schematic representation of the continuous lab‐scale process. ABSTRACT Monoclonal antibodies (mAbs) are nowadays fundamental in treating a wide range of severe diseases, including cancer, infections, or autoimmune disorders. Due to their high specificity, potent activity, and fewer side effects compared to small molecular drugs, the market for mAbs is ...
Thomas Kruse, Fabian Schmitz, Janina Kilian, Jonas Austerjost, Lucas‐Nik Reger, Markus Kampmann   +5 more
wiley   +1 more source

ModuloStat: An Internet of Things' Path to Continuous Cultures in Mini-Bioreactors. [PDF]

ACS Omega
Guérin C, Dervyn E, Véron J, Tanneur I, Dérozier S, Calabre M, Bidnenko E, Jules M, Nicolas P.   +8 more
europepmc   +1 more source

Hydrogel Embedding of Mesenchymal Stem Cells Supports Extracellular Vesicle Production

Biotechnology and Bioengineering, EarlyView.
This study investigates the effects of 3D culture conditions on extracellular vesicle (EV) production by mesenchymal stem cells (MSCs) in a gelatin‐based hydrogel matrix (GelMA). The EVs from both conditions were found to have similar morphological, molecular, and functional properties, but 3D cultures produced more total EVs per volume.
Rachel K. Moen, Gabriella Faircloth, Nicole T. Marguerite, Mariachiara Conti, Ethan S. Lippmann, Jamey D. Young   +5 more
wiley   +1 more source

Miniature bioreactor arrays for modeling functional and structural dysbiosis in inflammatory bowel disease. [PDF]

Gut Microbes
Newman KL, Standke AK, James G, Vendrov KC, Inohara N, Bergin IL, Higgins PDR, Rao K, Young VB, Kamada N.   +9 more
europepmc   +1 more source

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich, Maelia Dziedzic, Jia Sun, Sri Harsha Adusumilli, Carla Gonçalves, Chris Todd Hittinger, Brian F. Pfleger   +6 more
wiley   +1 more source