Results 221 to 230 of about 182,780 (336)

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

open access: yesBiotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya   +7 more
wiley   +1 more source

Analysis of the economic viability and environmental impacts of a conceptual process model for the recovery of lactic acid from spent media in cultivated meat production

open access: yesBiotechnology Progress, EarlyView.
Abstract Scaled production of cultivated meat (CM) will co‐produce large volumes of spent media. Recycling of abundant metabolites such as lactic acid in spent media offers an opportunity for valorization and reduction of the carbon footprint of CM production; however, the feasibility has yet to be examined.
Josh Wimble   +2 more
wiley   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

open access: yesBiotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu   +6 more
wiley   +1 more source

Electrocatalytic CO2 Reduction Coupled to Formate Fermentation: An Electro‐Bio Cascade Approach in Biocompatible Electrolytes

open access: yesChemistry – A European Journal, EarlyView.
CO2 utilization in industrial biotechnology: Rational design of a process cascade for electrochemical CO2 reduction linked with formate fermentation, supporting robust cell growth and high biomass yields. ABSTRACT Integration of electrochemical CO2 reduction with microbial fermentation enables conversion of CO2 into valuable chemicals but poses ...
Luciana Vieira   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy