Results 31 to 40 of about 71,391 (320)
Bioresources and Bioprocessing, 2022 Ansamitocin P-3 (AP-3) produced by Actinosynnema pretiosum is a potent antitumor agent. However, lack of efficient genome editing tools greatly hinders the AP-3 overproduction in A. pretiosum.
Siyu Guo +6 more
doaj +1 more source
In vivo learning-based control of microbial populations density in bioreactors [PDF]
arXiv, 2023 A key problem toward the use of microorganisms as bio-factories is reaching and maintaining cellular communities at a desired density and composition so that they can efficiently convert their biomass into useful compounds. Promising technological platforms for the real time, scalable control of cellular density are bioreactors.
arxiv
Bioreactors get personal [PDF]
OncoImmunology, 2012 Adoptive cell transfer immunotherapy against melanoma is highly effective. However, this therapy has seen limited dissemination, mainly due to the complexity and costs of cell expansion protocols. Two bioreactors have recently been described that simplify and streamline the production of individualized cell therapies.
Robert Somerville, Mark E. Dudley
openaire +3 more sources
Bioresources and Bioprocessing, 2023 During the ex vivo expansion of umbilical cord-derived mesenchymal stem cells (hUCMSCs) in a stirred tank bioreactor, the formation of cell–microcarrier aggregates significantly affects cell proliferation and physiological activity, making it difficult ...
Botao Zhang +6 more
doaj +1 more source
Bioresources and Bioprocessing, 2019 Background Ansamitocin P-3 (AP-3), produced by Actinosynnema pretiosum, has extraordinary antitumor activity and has been used as toxic “warhead” in antibody-conjugated drugs. However, AP-3 production is limited by its low yield and thus the high cost of
Ting Liu +4 more
doaj +1 more source
Mathematical modeling and numerical simulation of a bioreactor landfill using Feel++ [PDF]
ESAIM: Proceedings and Surveys, 55:83--110 (2016), 2016 In this paper, we propose a mathematical model to describe the functioning of a bioreactor landfill, that is a waste management facility in which biodegradable waste is used to generate methane. The simulation of a bioreactor landfill is a very complex multiphysics problem in which bacteria catalyze a chemical reaction that starting from organic carbon
arxiv +1 more source
Biotechnology for Biofuels, 2018 Background Lignocellulose is one of the most promising alternative feedstocks for glutamic acid production as commodity building block chemical, but the efforts by the dominant industrial fermentation strain Corynebacterium glutamicum failed for ...
Jingbai Wen +4 more
doaj +1 more source
Evolution of an in vivo bioreactor [PDF]
Journal of Orthopaedic Research, 2005 AbstractThe ideal bone graft substitute requires osteoconductive, osteoinductive, and osteogenic components. This study introduces an “in vivo bioreactor,” a model in which pluripotent cells are recruited from circulating blood to a vascularized coralline scaffold supplemented with bone morphogenetic protein‐2 (BMP‐2).
Ginger E. Holt +4 more
openaire +3 more sources
Bioresources and Bioprocessing, 2019 Background A rational and high-performance high-throughput screening system effectively improves the efficiency of strain screening. Results A rapid and efficient method was developed to detect carbon sources.
Yumeng Lin +4 more
doaj +1 more source
Bioresources and Bioprocessing, 2022 Background β-Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide coenzymes such as NAD+ and NADP+, which are widely applied in industrial biocatalysis especially involving cofactor-dependent oxidoreductases.
Xiao-Long Qian +5 more
doaj +1 more source