Results 1 to 10 of about 114,435 (209)

BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]

PLoS Genetics, 2018
A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
doaj   +4 more sources

A whole-body atlas of BMP signaling activity in an adult sea anemone [PDF]

BMC Biology
Background BMP signaling is responsible for the second body axis patterning in Bilateria and in the bilaterally symmetric members of the bilaterian sister clade Cnidaria—corals and sea anemones.
Paul Knabl, David Mörsdorf, Grigory Genikhovich   +2 more
doaj   +2 more sources

BMP signaling in cancer stemness and differentiation. [PDF]

Cell Regen, 2023
AbstractThe BMP (Bone morphogenetic protein) signaling pathway plays a central role in metazoan biology, intricately shaping embryonic development, maintaining tissue homeostasis, and influencing disease progression. In the context of cancer, BMP signaling exhibits context-dependent dynamics, spanning from tumor suppression to promotion.
Zhou W, Yan K, Xi Q.
europepmc   +4 more sources

Positional BMP signaling orchestrates villus length in the small intestine [PDF]

Nature Communications
The intestinal epithelium undergoes fast turnover, and the villus length in the small intestine gradually decreases from the duodenum to the ileum. However, the underlying mechanisms remain poorly understood.
Xu Wang, Siqi Li, Yuan Liu, Xiangyu Kuang, Jianxin Chen, Pei Yu, Lianzheng Zhao, Ze Zhang, Meimei Huang, Liansheng Liu, Mengxian Zhang, Yalong Wang, Weizhi Ji, Jinsong Li, Lei Zhang, Ye-Guang Chen   +15 more
doaj   +2 more sources

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress [PDF]

Nature Communications
In contrast to mammals, adult zebrafish achieve complete heart regeneration via proliferation of cardiomyocytes. Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue ...
Mohankrishna Dalvoy Vasudevarao, Denise Posadas Pena, Michaela Ihle, Chiara Bongiovanni, Pallab Maity, Dominik Geissler, Hossein Falah Mohammadi, Melanie Rall-Scharpf, Julian Niemann, Mathilda T. M. Mommersteeg, Simone Redaelli, Kathrin Happ, Chi-Chung Wu, Arica Beisaw, Karin Scharffetter-Kochanek, Gabriele D’Uva, Mona Malek Mohammadi, Lisa Wiesmüller, Hartmut Geiger, Gilbert Weidinger   +19 more
doaj   +2 more sources

Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans

Cell & Bioscience, 2022
Background Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer’s disease, obesity, and cardiovascular disease.
Mehul Vora, Arindam Mondal, Dongxuan Jia, Pranya Gaddipati, Moumen Akel, John Gilleran, Jacques Roberge, Christopher Rongo, John Langenfeld   +8 more
doaj   +1 more source

Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2017
The highly conserved bone morphogenetic protein (BMP) signaling pathway regulates many developmental and homeostatic processes. While the core components of the BMP pathway have been well studied, much research is needed for understanding the mechanisms ...
Lin Wang, Zhiyu Liu, Herong Shi, Jun Liu
doaj   +1 more source

BMP signaling in axon regeneration [PDF]

Current Opinion in Neurobiology, 2014
Neuronal competence to re-extend axons and a permissive environment that allows growth cone navigation are two major determinants for successful axon regeneration. Here, we review the roles of bone morphogenetic protein (BMP) signaling in mediating both neuronal and glial injury responses after CNS injury.
Jian, Zhong, Hongyan, Zou
openaire   +2 more sources

Extracellular regulation of BMP signaling [PDF]

Current Biology, 2010
In the developing organism, cells differentiate, divide and die as part of groups of hundreds or thousands of cells called 'morphogenetic fields'. Fields have the remarkable property of self-regulation: for example, if the forelimb field is bisected, each half can give rise to a complete limb after transplantation, as discovered by Ross Harrison in ...
Zakin, Lise, De Robertis, E.M.
openaire   +2 more sources

BMP Signaling Pathway in Dentin Development and Diseases

Cells, 2022
BMP signaling plays an important role in dentin development. BMPs and antagonists regulate odontoblast differentiation and downstream gene expression via canonical Smad and non-canonical Smad signaling pathways.
Mengmeng Liu, Graham Goldman, Mary MacDougall, Shuo Chen   +3 more
doaj   +1 more source