Results 11 to 20 of about 114,435 (209)
Frontiers in Cell and Developmental Biology, 2020 The bone morphogenetic protein (BMP) signaling pathway is highly conserved across many species, and its importance for the patterning of the skeletal system has been demonstrated.
Guiqian Chen +7 more
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PLoS Biology, 2021 Bone Morphogenetic Protein (BMP) patterns the dorsal-ventral (DV) embryonic axis in all vertebrates, but it is unknown how cells along the DV axis interpret and translate the gradient of BMP signaling into differential gene activation that will give rise
Hannah Greenfeld +2 more
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Pentagone: patrolling BMP morphogen signaling [PDF]
Fly, 2011 Orchestration of spatial organization by signaling gradients--morphogen gradients--is a fundamental principle in animal development. Despite their importance in tissue patterning and growth, the exact mechanisms underlying the establishment and maintenance of morphogen gradients are poorly understood. Our recent work on BMP (bone morphogenetic protein)
Vuilleumier, Robin +2 more
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BMP signaling in vascular diseases [PDF]
FEBS Letters, 2012 Bone morphogenetic proteins (BMPs) are members of the transforming growth factor‐β (TGF‐β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone ...
Cai, J. +3 more
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Optogenetic investigation of BMP target gene expression diversity
eLife, 2020 Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis.
Katherine W Rogers +3 more
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BRITER: a BMP responsive osteoblast reporter cell line. [PDF]
PLoS ONE, 2012 BACKGROUND: BMP signaling pathway is critical for vertebrate development and tissue homeostasis. High-throughput molecular genetic screening may reveal novel players regulating BMP signaling response while chemical genetic screening of BMP signaling ...
Prem Swaroop Yadav +2 more
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Frontiers in Physiology, 2023 Cranial neural crest cells (NCCs) are the origin of the anterior part of the face and the head. Cranial NCCs are multipotent cells giving rise to bones, cartilage, adipose-tissues in the face, and neural cells, melanocytes, and others.
Hiroki Ueharu, Yuji Mishina
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Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
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Specification of BMP Signaling
Cells, 2019 Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor (TGF)β family and represent secreted growth factors, which play an essential role in many aspects of cell communication in higher organisms.
Joachim Nickel, Thomas D. Mueller
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The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. [PDF]
PLoS ONE, 2015 Bone Morphogenetic Proteins (BMPs) form a group of secreted factors that belongs to the TGF-β superfamily. Among different roles in a number of immune cell types, BMPs are known to regulate T cell development within the thymus, although the role of BMP ...
Víctor G Martínez +7 more
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