Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints
Cell Reports, 2015 BMP signaling plays a crucial role in the establishment of the dorso-ventral body axis in bilaterally symmetric animals. However, the topologies of the bone morphogenetic protein (BMP) signaling networks vary drastically in different animal groups ...
Grigory Genikhovich +8 more
doaj +1 more source
Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]
, 2013 The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Flinspach, Armin Niklas +5 more
core +1 more source
Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
Pulmonary Circulation, 2022 BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling ...
Bin Liu +8 more
doaj +1 more source
Assessment of BMP responses in an in vitro model of acute ethanol toxicity
MethodsX, 2022 The assay presented here was designed to assess the immediate effects of ethanol (EtOH) exposure on intracellular signaling activated by BMPs (Bone Morphogenetic Proteins).
Naila Habeeb +2 more
doaj +1 more source
BMP signalling in craniofacial development
The International Journal of Developmental Biology, 2006 The BMP signalling pathway is conserved throughout evolution and essential for mammalian embryonic and postnatal development and growth. In the vertebrate head, this signal is involved in the development of a variety of structures and shows divergent roles.
Xuguang, Nie +2 more
openaire +3 more sources
TAK1 mediates BMP signaling in cartilage [PDF]
Annals of the New York Academy of Sciences, 2010 Although many signals are capable of activating MAPK signaling cascades in chondrocytes in vitro, the function of these pathways remains unclear in vivo. Here we report the phenotype of mice with a conditional deletion of TGF‐β‐activated kinase 1 (TAK1), a MAP3K family member, in cartilage using the collagen 2α promoter.
Matthew B, Greenblatt +2 more
openaire +2 more sources
A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. [PDF]
PLoS ONE, 2012 Insights into Bone morphogenetic protein (Bmp) functions during forebrain development have been limited by a lack of Bmp signaling readouts. Here we used a novel Bmp signaling reporter ("BRE-gal" mice) to study Bmp signaling in the dorsal telencephalon ...
Linda T Doan +5 more
doaj +1 more source
Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
PLoS Biology, 2012 Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side.
Yi-Jyun Luo, Yi-Hsien Su
doaj +1 more source
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]
, 2013 Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor +75 more
core +2 more sources
Bmp induces osteoblast differentiation through both Smad4 and mTORC1 signaling [PDF]
, 2017 The bone morphogenetic protein (Bmp) family of secreted molecules has been extensively studied in the context of osteoblast differentiation. However, the intracellular signaling cascades that mediate the osteoblastogenic function of Bmp have not been ...
Karner, Courtney M +2 more
core +2 more sources