HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
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BNIP3 is a key driver of breast cancer progression and a novel glycolysis-regulating biomarker [PDF]
Scientific ReportsBreast cancer (BC) represents a leading cause of cancer-related mortality among women, with glycolysis and immunomodulation playing pivotal roles in its progression. This study, by integrating bioinformatics analyses and in vitro and in vivo experiments,
Lichen Cao +5 more
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TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice [PDF]
Communications BiologyIntestinal damage following interrupted blood flow and its return (intestinal ischemia/reperfusion injury) is a serious medical problem occurring in various clinical situations.
Jinping Nie +12 more
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Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy [PDF]
Frontiers in OncologyBackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is implicated in autophagy and ...
Long Huang +11 more
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HIF1A/BNIP3 pathway affects ferroptosis in sepsis-induced cardiomyopathy through binding to BCL-2 [PDF]
Redox ReportBackground: Sepsis-induced cardiomyopathy (SIC) involves ferroptosis, an iron-dependent cell death. Hypoxia-inducible factor-1α (HIF-1α) regulates autophagy and apoptosis, but its role in ferroptosis remains unclear.
Xiaoyue Wang +6 more
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Autophagy/ Apoptosis Induced by Geraniol through HIF-1α/BNIP3/Beclin-1 Signaling Pathway in A549 CoCl2 Treated Cells [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: During cancer growth, hypoxia occurs along with autophagy as an adaptive responseto overcome cellular stress. Geraniol (GE) is a natural isoprenoid known for its wide anticanceractivity and autophagy induction in the cancer cell.
Dina M. Abo El-Ella
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Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis [PDF]
Archives of Biological Sciences, 2022 Excessive apoptosis of intervertebral disk cells and intervertebral disk degeneration (IDD) is the prime cause of low back pain. B-cell lymphoma 2 (Bcl-2) and adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member of the Bcl-2 family, are involved
Tingsheng Wu +5 more
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The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. [PDF]
PLoS ONE, 2014 BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway. We reported previously that mitochondrial localization of BNIP3 and translocation of EndoG from mitochondria to the nucleus are critical steps of the BNIP3 ...
Xiaosha Zhang, Xiuwu Bian, Jiming Kong
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The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation. [PDF]
PLoS ONE, 2018 The BH3-only family member BNIP3 has been described as either promoting cell survival or cell death. This depends upon the level of BNIP3 expression and its cellular localization. Increased BNIP3 expression under hypoxia contributes to cell death through
Amandeep Singh +6 more
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Scientific Reports, 2021 Preeclampsia (PE) is a severe multisystem pregnancy complication characterized by gestational hypertension and proteinuria. Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is a mediator of mitophagy and has been proven to be associated with PE,
Xiaobo Zhou +6 more
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