Results 1 to 10 of about 21,955 (252)
VDR restores the expression of PINK1 and BNIP3 in TECs of streptozotocin-induced diabetic mice
Life Science AllianceVDR protects against fibrosis and defective mitophagy in diabetic mice by regulating mitophagy-related proteins PINK1 and BNIP3. Defective mitophagy in renal tubular epithelial cells is one of the main drivers of renal fibrosis in diabetic kidney disease.
Cheng Yang +10 more
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Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis [PDF]
Archives of Biological Sciences, 2022 Excessive apoptosis of intervertebral disk cells and intervertebral disk degeneration (IDD) is the prime cause of low back pain. B-cell lymphoma 2 (Bcl-2) and adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member of the Bcl-2 family, are involved
Tingsheng Wu +5 more
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The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. [PDF]
PLoS ONE, 2014 BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway. We reported previously that mitochondrial localization of BNIP3 and translocation of EndoG from mitochondria to the nucleus are critical steps of the BNIP3 ...
Xiaosha Zhang, Xiuwu Bian, Jiming Kong
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The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation. [PDF]
PLoS ONE, 2018 The BH3-only family member BNIP3 has been described as either promoting cell survival or cell death. This depends upon the level of BNIP3 expression and its cellular localization. Increased BNIP3 expression under hypoxia contributes to cell death through
Amandeep Singh +6 more
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Scientific Reports, 2021 Preeclampsia (PE) is a severe multisystem pregnancy complication characterized by gestational hypertension and proteinuria. Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is a mediator of mitophagy and has been proven to be associated with PE,
Xiaobo Zhou +6 more
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BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia
Cell Death and Disease, 2022 Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria.
Yun-Ling He +11 more
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Cells, 2020 The Insulin-like Growth Factor I (IGF-1) signalling pathway is essential for cell growth and facilitates tumourogenic processes. We recently reported that IGF-1 induces a transcriptional programme for mitochondrial biogenesis, while also inducing ...
Sarah Riis +2 more
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Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy. [PDF]
PLoS ONE, 2015 BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein induces mitochondrial dysfunction, often leading to cell death.
Katherine E Liu, William A Frazier
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BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. [PDF]
PLoS ONE, 2012 Mieap, a p53-inducible protein, controls mitochondrial quality by repairing unhealthy mitochondria. During repair, Mieap induces the accumulation of intramitochondrial lysosomal proteins (designated MALM for Mieap-induced accumulation of lysosome-like ...
Yasuyuki Nakamura +7 more
doaj +1 more source
Hematology, 2023 Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria ...
Pingping Xiao +7 more
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