Results 91 to 100 of about 19,187 (211)

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia

Cancers
Background and Aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths. Previous studies showed muscle proteolysis hyper-activation and mitophagy induction in tumor-bearing animals.
Claudia Fornelli, Marc Beltrà, Antonio Zorzano, Paola Costelli, David Sebastian, Fabio Penna   +5 more
openaire   +3 more sources

Distinct Pathways Regulate Proapoptotic Nix and BNip3 in Cardiac Stress [PDF]

Journal of Biological Chemistry, 2006
Up-regulation of myocardial Nix and BNip3 is associated with apoptosis in cardiac hypertrophy and ischemia, respectively. To identify mechanisms of gene regulation for these critical cardiac apoptosis effectors, the determinants of Nix and BNip3 promoter activation were elucidated by luciferase reporter gene expression in neonatal rat cardiac myocytes.
Anita S, Gálvez, Eric W, Brunskill, Yehia, Marreez, Bonnie J, Benner, Kelly M, Regula, Lorrie A, Kirschenbaum, Gerald W, Dorn   +6 more
openaire   +2 more sources

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia [PDF]

, 2016
Representative flow cytometric plots (FACS) showing that AMSCs expressed HLA-ABC, CD44, CD90, CD29, CD73, and CD105 markers, and did not express HLA-DR, CD45, CD14 or CD34 markers.
Ahmed Saad, Allan B. Dietz, Andre J. van Wijnen, Hui Tang, LaTonya Hickson, Lilach Lerman, Sandra Herrmann, Stephen Textor, Xiang-Yang Zhu   +8 more
core   +3 more sources

Cellular microenvironment of erythropoietin‐producing cells in hypoxic and injured mouse kidneys

Experimental Physiology, EarlyView.
Abstract The main sources of circulating erythropoietin (Epo) in the adult are kidney Norn cells, a recently identified interstitial cell type capable of becoming renal Epo‐producing (REP) cells following a local decrease in tissue oxygenation. REP cells are restricted to small clusters in the corticomedullary border region, suggesting that their ...
Olga M. Lempke, Thomas Knöpfel, Stellor Nlandu Khodo, Roland H. Wenger   +3 more
wiley   +1 more source

Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Journal of Translational Medicine, 2012
Background This study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal ...
Jin Ting, Lin Huan-Xin, Lin Hui, Guo Li-Bing, Ge Nan, Cai Xiu-Yu, Sun Rui, Chen Wen-Kuan, Li Qiu-Li, Hu Wei-Han   +9 more
doaj   +1 more source

Mitochondrial dynamics and quality control in Huntington's disease [PDF]

, 2015
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by polyglutamine expansion mutations in the huntingtin protein. Despite its ubiquitous distribution, expression of mutant huntingtin (mHtt) is particularly detrimental to medium ...
de Proença, J, Duchen, MR, Guedes-Dias, P, Oliveira, JM, Pinho, BR, Soares, TR   +5 more
core   +1 more source

Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells

The Journal of Physiology, EarlyView.
Abstract figure legend Knockdown of Septin7 alters the expression of markers responsible for mitochondrial dynamics. Members of the electron transport chain are also affected by diminished Septin7 level resulting in functional changes of mitochondrial respiration. Abstract Mitochondria are dynamic organelles that undergo fusion and fission.
Andrea Telek, Ivett Gabriella Szabó, Anikó Keller‐Pintér, Mónika Gönczi, Eliza Guti, László Szabó, Brigitta Tillmann, Zoltán Márton Kohler, László Juhász, Péter Bai, Szilárd Póliska, Zsuzsanna Gaál, László Csernoch, János Fodor   +13 more
wiley   +1 more source

Regulation of Mitochondrial Integrity, Autophagy and Cell Survival by BNIP3 [PDF]

Autophagy, 2007
Understanding the role of BNIP3 in the systemic response to hypoxia has been complicated by conflicting results that indicate on the one hand that BNIP3 promotes cell death, and other data, including our own that BNIP3 is not sufficient for cell death, but rather plays a critical role in hypoxia-induced autophagy.
Kristin, Tracy, Kay F, Macleod
openaire   +2 more sources

Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy

Journal of Pharmacological Sciences, 2018
Akebia Saponin D (ASD) is the most abundant constituent of the rhizome of Dipsacus asper Wall. The prior studies have shown that ASD alleviates hepatic steatosis targeted at the modulation of autophagy and exerts hepatoprotective effects through ...
Li-li Gong, Song Yang, Wen Zhang, Fei-fei Han, Ya-li Lv, Zi-Rui Wan, He Liu, Yang-jie Jia, Ling-ling Xuan, Li-hong Liu   +9 more
doaj   +1 more source