Results 101 to 110 of about 21,955 (252)

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Journal of Translational Medicine, 2019
Background The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis.
Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun   +15 more
doaj   +1 more source

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance [PDF]

, 2017
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin.
A Choudhury, A Hamacher-Brady, A Hoshino, A Kirchhofer, A Kuma, A Marchese, A Roczniak-Ferguson, A Zeigerer, AH Gaspar, C Campsteijn, C Raiborg, CH Davis, CS Zhang, D Narendra, DA Kubli, DA Kubli, DA Kubli, DC Rubinsztein, DJ Yamashiro, E Karwatowska-Prokopczuk, F Kanai, FR Maxfield, G Gong, G Twig, GL McLelland, GL McLelland, IH Lee, J Rink, JR Kremer, K Hayashida, K Hirosako, K Okatsu, KY Kim, M Komatsu, M Kundu, M Matsui, M Song, M Song, N Hariharan, NC McKnight, PA Ney, Q Sun, R Sahu, R Zoncu, RA Hanna, RN Day, S Geisler, S Hwang, S Jean, S Kaushik, S Phan, SG Roy, SJ Martin, SR Sriram, SR Yoshii, SS Lam, T Kitada, TD Cummins, TD Schmittgen, V Soubannier, WM Henne, WW Li, WX Ding, XM Liu, Y Chen, Y Nishida, Y Zhang, YR Chen   +67 more
core   +2 more sources

BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia

Cancers
Background and Aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths. Previous studies showed muscle proteolysis hyper-activation and mitophagy induction in tumor-bearing animals.
Claudia Fornelli, Marc Beltrà, Antonio Zorzano, Paola Costelli, David Sebastian, Fabio Penna   +5 more
openaire   +3 more sources

Distinct Pathways Regulate Proapoptotic Nix and BNip3 in Cardiac Stress [PDF]

Journal of Biological Chemistry, 2006
Up-regulation of myocardial Nix and BNip3 is associated with apoptosis in cardiac hypertrophy and ischemia, respectively. To identify mechanisms of gene regulation for these critical cardiac apoptosis effectors, the determinants of Nix and BNip3 promoter activation were elucidated by luciferase reporter gene expression in neonatal rat cardiac myocytes.
Anita S, Gálvez, Eric W, Brunskill, Yehia, Marreez, Bonnie J, Benner, Kelly M, Regula, Lorrie A, Kirschenbaum, Gerald W, Dorn   +6 more
openaire   +2 more sources

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Journal of Translational Medicine, 2012
Background This study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal ...
Jin Ting, Lin Huan-Xin, Lin Hui, Guo Li-Bing, Ge Nan, Cai Xiu-Yu, Sun Rui, Chen Wen-Kuan, Li Qiu-Li, Hu Wei-Han   +9 more
doaj   +1 more source

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain [PDF]

, 2017
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells.
Chen, Jia-Li, Qin, Zheng-Hong, Sheng, Rui, Song, Dan-Dan, Waeber, Christian, Xia, Yun-Fei, Zhang, Tong-Tong   +6 more
core   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. [PDF]

, 2019
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on ...
Andreyev, Alexander Yu, Bandyopadhyay, Guatam K, Beeman, Scott C, Cabrales, Pedro, Huh, Jin Young, Klein, Samuel, Lee, Yun Sok, Murphy, Anne N, Olefsky, Jerrold M, Riopel, Matthew, Seo, Jong Bae, Smith, Gordon I   +11 more
core  

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia [PDF]

, 2016
Representative flow cytometric plots (FACS) showing that AMSCs expressed HLA-ABC, CD44, CD90, CD29, CD73, and CD105 markers, and did not express HLA-DR, CD45, CD14 or CD34 markers.
Ahmed Saad, Allan B. Dietz, Andre J. van Wijnen, Hui Tang, LaTonya Hickson, Lilach Lerman, Sandra Herrmann, Stephen Textor, Xiang-Yang Zhu   +8 more
core   +3 more sources