Results 141 to 150 of about 21,955 (252)

FoxG1/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcoma

Cancer Science
Cisplatin (CDDP) is a commonly used chemotherapeutic for osteosarcoma (OS) patients, and drug resistance remains as a major hurdle to undermine the treatment outcome.
Baolong Pan, Yan Li, Hu Han, Lu Zhang, Xuemei Hu, Yanyu Pan, Zhuohui Peng   +6 more
semanticscholar   +1 more source

Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

Life Science Alliance
The mitochondrial phosphatase PPTC7 was previously found to suppress mitophagy, but the underlying mechanisms were unclear. Here, the authors show that PPTC7 dynamically localizes to the outer mitochondrial membrane to promote the turnover of the ...
Lianjie Wei, M. Gok, Jordyn D Svoboda, Keri-Lyn Kozul, Merima Forny, Jonathan R. Friedman, Natalie M. Niemi   +6 more
semanticscholar   +1 more source

BNIP3-dependent mitophagy role in cisplatin resistance

Autophagy Reports, 2022
Cocetta V., Vianello C., Giacomello M., Montopoli M.   +3 more
openaire   +3 more sources

GSK-3α-BNIP3 axis promotes mitophagy in human cardiomyocytes under hypoxia

bioRxiv
Dysregulated autophagy/mitophagy is one of the major causes of cardiac injury in ischemic conditions. Glycogen synthase kinase-3alpha (GSK-3α) has been shown to play a crucial role in the pathophysiology of cardiac diseases.
H. Marzook, Anamika Gupta, M. Jayakumar, Mohamed A. Saleh, D. Tomar, R. Qaisar, Firdos Ahmad   +6 more
semanticscholar   +1 more source

Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy

Frontiers in Oncology
BackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is implicated in autophagy and ...
Long Huang, Lin Wang, Dan Yuan, Yan Xu, Yu Wang, Kai Yao, Xiao Zhong, Quanda Liu, Kang Jia, Lei Lei, Haiyan Wang, Dongliang Liu   +11 more
doaj   +1 more source

Rictor/mTORC2 signalling contributes to renal vascular endothelial‐to‐mesenchymal transition and renal allograft interstitial fibrosis by regulating BNIP3‐mediated mitophagy

Clinical and Translational Medicine
Background Renal allograft interstitial fibrosis/tubular atrophy (IF/TA) constitutes the principal histopathological characteristic of chronic allograft dysfunction (CAD) in kidney‐transplanted patients.
Dengyuan Feng, Zeping Gui, Zhen Xu, Jianjian Zhang, Bin Ni, Zijie Wang, Jiawen Liu, Shuang Fei, Hao Chen, Li Sun, Min Gu, R. Tan   +11 more
semanticscholar   +1 more source

Purification of BNIP3-GFP v1

This protocol details the purification of BNIP3-GFP.
openaire   +1 more source

EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes.

PLoS ONE, 2011
Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic pathway and their death during ...
Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A Cook, Joan X Comella, Daniel Sanchis   +9 more
doaj   +1 more source

Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3 [PDF]

, 2018
.: hBok is a human pro-apoptotic member of the Bcl-2 family. By fluorescence in situ hybridization and in silico analysis, hBok was found to be located on chromosome 2q37.3.
Dürrenberger, M., Fu, W., Gao, S., Geyter, C., Zhang, H.   +4 more
core  

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. [PDF]

, 2019
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment.
Fan, Li, Feng, Jianbo, Fu, Haijuan, Li, Guiyuan, Li, Peiyao, Liu, Changhong, Liu, Qiang, Liu, Qing, Ren, Xing, She, Xiaoling, Sun, Yingnan, Wu, Minghua, Zhang, Yan, Zhao, Chunhua   +13 more
core   +1 more source