Results 11 to 20 of about 21,955 (252)
HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +5 more sources
Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features [PDF]
BMC Cancer, 2009 Background Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been described in human tumors, including gastrointestinal tumors, resulting ...
de Weger Roel A +5 more
doaj +2 more sources
BNIP3 in melanoma: isn’t it IRONic? [PDF]
Molecular & Cellular Oncology, 2021 Melanoma cells exploit mitophagy and hypoxia signaling to promote their growth. In a recent study, we found that loss of B-cell lymphoma 2 (BCL-2)/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3) curbed Hypoxia Inducible Factor 1 alpha (HIF-1α)
Mónica Vara-Pérez, Patrizia Agostinis
doaj +3 more sources
ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3 [PDF]
Scientific Reports, 2021 UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins.
Logan P. Poole +3 more
doaj +4 more sources
Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death [PDF]
Autophagy, 2012 Hypoxia-inducible pro-death protein BNIP3 (BCL-2/adenovirus E1B 19-kDa interacting protein 3), provokes mitochondrial permeabilization causing cardiomyocyte death in ischemia-reperfusion injury.
Diwan, Abhinav +3 more
core +6 more sources
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4
EMBO ReportsMitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors, and FBXL4 ...
Giang Thanh Nguyen-Dien +17 more
doaj +2 more sources
BNIP3 is a key driver of breast cancer progression and a novel glycolysis-regulating biomarker [PDF]
Scientific ReportsBreast cancer (BC) represents a leading cause of cancer-related mortality among women, with glycolysis and immunomodulation playing pivotal roles in its progression. This study, by integrating bioinformatics analyses and in vitro and in vivo experiments,
Lichen Cao +5 more
doaj +2 more sources
Redox BiologyAims: Doxorubicin is a powerful chemotherapeutic agent for cancer, whose use is limited due to its potential cardiotoxicity. Semaglutide (SEMA), a novel analog of glucagon-like peptide-1 (GLP-1), has received widespread attention for the treatment of ...
Xiaoping Li +13 more
doaj +2 more sources
Cell Death and DiseaseMitophagy is a selective process that targets the damaged, dysfunctional, or superfluous mitochondria for degradation through autophagy. The SCFFBXL4 E3 ubiquitin ligase complex suppresses basal mitophagy by targeting BNIP3 and BNIP3L, two key mitophagy ...
Xiayun Xu +9 more
doaj +2 more sources
ERVWE1 Impairs Mitochondrial Homeostasis and Promotes Neuronal Apoptosis via the miR-27b-3p/BNIP3 Axis in Schizophrenia [PDF]
VirusesSchizophrenia is a severe neurodevelopmental disorder with a complex and largely unresolved pathogenesis. Accumulating evidence indicates that mitochondrial dysfunction is a consistent pathological hallmark of schizophrenia, suggesting that impaired ...
Yaru Su +8 more
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