Bnip3 - Open Access .click

Biochemistry (Moscow), 2020
BNIP3 is a member of Bcl-2 protein family involved in regulation of various forms of cell death. However, its role in these processes remains unclear and varies depending on the type of cancer cells and environmental factors (pH, O2 level, etc.). Here, the role of BNIP3 in apoptosis regulation in lung adenocarcinoma cells was investigated.
A S, Gorbunova +6 more
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BNIP3 and Nix: Atypical regulators of cell fate

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
Since their discovery nearly 25 years ago, the BCL-2 family members BNIP3 and BNIP3L (aka Nix) have been labelled 'atypical'. Originally, this was because BNIP3 and Nix have divergent BH3 domains compared to other BCL-2 proteins. In addition, this atypical BH3 domain is dispensable for inducing cell death, which is also unusual for a 'death gene ...
Jared T, Field, Joseph W, Gordon
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BNIP3 Regulation of Intracellular Calcium

The FASEB Journal, 2016
Necrotizing enterocolitis is the most common gastrointestinal emergency affecting low‐birth weight premature infants, with an incidence between 3% and 10% in infants less than 1500 grams, and mortality ranging from 15% to 30%. The pathogenesis of NEC is not clearly defined, but is likely a multifactorial disease wherein intestinal ischemia and hypoxia ...
Jared Field +5 more
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mitophagy
medicine
autophagy

cytology
apoptosis
hypoxia

hif-1α
including cancer and carcinogens
oncology