Results 21 to 30 of about 19,187 (211)
Hematology, 2023 Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria ...
Pingping Xiao +7 more
doaj +1 more source
BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. [PDF]
PLoS ONE, 2012 Mieap, a p53-inducible protein, controls mitochondrial quality by repairing unhealthy mitochondria. During repair, Mieap induces the accumulation of intramitochondrial lysosomal proteins (designated MALM for Mieap-induced accumulation of lysosome-like ...
Yasuyuki Nakamura +7 more
doaj +1 more source
Cells, 2022 Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF.
Antoine H. Chaanine +5 more
doaj +1 more source
Cell Death and Disease, 2022 Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in ESCs remain largely unknown.
Qian Zhao +9 more
doaj +1 more source
Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
core +4 more sources
Cells, 2019 : Stem cells isolated from the apical papilla of wisdom teeth (SCAPs) are an attractive model for tissue repair due to their availability, high proliferation rate and potential to differentiate in vitro towards mesodermal and neurogenic lineages.
Murielle Rémy +8 more
doaj +1 more source
Role of BNIP3 in TNF-induced cell death — TNF upregulates BNIP3 expression
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic) and caspase-independent (necrosis-like) cell death in different cells. We used the murine fibrosarcoma cell line model L929 and a stable L929 transfectant over-expressing a mutated dominant-negative form of BNIP3 lacking the C-terminal transmembrane (TM) domain ...
Ghavami, Saeid +9 more
openaire +3 more sources
BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton [PDF]
, 2014 BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending on the type of stress and cellular context.
Agostinis, P +8 more
core +2 more sources
MicroRNA145 Targets BNIP3 and Suppresses Prostate Cancer Progression [PDF]
Cancer Research, 2010 Abstract The putative tumor suppressor miR145 is transcriptionally regulated by TP53 and is downregulated in many tumors; however, its role in prostate cancer is unknown. On the other hand, BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is overexpressed in various tumors, including prostate cancer, and may transcriptionally ...
Xueqin, Chen +11 more
openaire +2 more sources
DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming
BMC Genomics, 2018 Background Environmental changes of biotic or abiotic nature during critical periods of early development may exert a profound influence on physiological functions later in life.
Vincent Veron +7 more
doaj +1 more source