Results 31 to 40 of about 19,187 (211)
A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]
, 2007 Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Ceriello, Antonio +6 more
core +3 more sources
Deficit of female sex hormones desensitizes rat cardiac mitophagy
Chinese Journal of Physiology, 2021 Long-term deprivation of female sex hormones has been shown to mediate accumulation of damaged mitochondria in ventricular muscle leading to cardiovascular dysfunction.
Theerachat Kampaengsri +3 more
doaj +1 more source
BNIP3 expression in follicular lymphoma
Histopathology, 2007 Aims: To investigate the role of BNIP3, a 19‐kDa interacting protein of the Bcl‐2 family, alongside Bcl‐2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase‐3 (apoptotic markers) and Ki67 (proliferation marker).Methods and results: Immunohistochemistry using monoclonal ...
Sington, J +5 more
openaire +2 more sources
Bnip3-mediated defects in oxidative phosphorylation promote mitophagy [PDF]
Autophagy, 2011 The Bcl-2 proteins are best known as regulators of the intrinsic mitochondrial pathway of apoptosis. However, recent studies have demonstrated that they can also regulate autophagy. For many years, autophagy was considered to be a nonselective process where the autophagosomes randomly sequestered contents in the cytosol to supply the cells with amino ...
Robert L, Thomas +2 more
openaire +2 more sources
Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.
PLoS ONE, 2015 Bnip3 is a hypoxia-regulated member of the Bcl-2 family of proteins that is implicated in apoptosis, programmed necrosis, autophagy and mitophagy. Mitochondria are thought to be the primary targets of Bnip3 although its activities may extend to the ER ...
John W Thompson +7 more
doaj +1 more source
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]
, 2014 Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne +3 more
core +2 more sources
Autophagy and BNIP3 protein in tumorogenesis
Postępy Higieny i Medycyny Doświadczalnej, 2013 Autophagy is a process necessary for maintaining cell homeostasis in physiological conditions, as well as during certain stresses like nutrients or oxygen deprivation. Autophagy also plays an essential role in tumorigenesis. It prevents cell transformation, but on the other hand, autophagy enables existing cancer cells to adapt to harmful conditions ...
Ewelina, Swiderek, Leon, Strządała
openaire +2 more sources
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. [PDF]
, 2016 Mitochondria abnormalities in skeletal muscle may contribute to frailty and sarcopenia, commonly present in patients with chronic kidney disease (CKD).
Billings, Frederic T +9 more
core +1 more source
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
doaj +1 more source
Parkin-independent mitophagy controls chemotherapeutic response in cancer cells [PDF]
, 2017 Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Bossowski, Jozef P. +13 more
core +2 more sources