Results 31 to 40 of about 21,955 (252)

BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination

Cell Death and Disease, 2022
Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in ESCs remain largely unknown.
Qian Zhao, Kun Liu, Lin Zhang, Zheng Li, Liang Wang, Jiani Cao, Youqing Xu, Aihua Zheng, Quan Chen, Tongbiao Zhao   +9 more
doaj   +1 more source

Parkin-independent mitophagy controls chemotherapeutic response in cancer cells [PDF]

, 2017
Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Bossowski, Jozef P., Chiche, Johanna, Marchetti, Sandrine, Mondragón, Laura, Obba, Sandrine, Proïcs, Emma, Ricci, Jean-Ehrland, Riley, Joel S., Rozier, Romain M., Rubio-Patiño, Camila, Tait, Stephen W.G., Verhoeyen, Els, Villa, Elodie, Zunino, Barbara   +13 more
core   +6 more sources

DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming

BMC Genomics, 2018
Background Environmental changes of biotic or abiotic nature during critical periods of early development may exert a profound influence on physiological functions later in life.
Vincent Veron, Lucie Marandel, Jingwei Liu, Emilio J. Vélez, Olivier Lepais, Stéphane Panserat, Sandrine Skiba, Iban Seiliez   +7 more
doaj   +1 more source

Role of BNIP3 in TNF-induced cell death — TNF upregulates BNIP3 expression

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic) and caspase-independent (necrosis-like) cell death in different cells. We used the murine fibrosarcoma cell line model L929 and a stable L929 transfectant over-expressing a mutated dominant-negative form of BNIP3 lacking the C-terminal transmembrane (TM) domain ...
Ghavami, Saeid, Eshraghi, Mehdi, Kadkhoda, Kamran, Mutawe, Mark M., Maddika, Subbareddy, Bay, Graham H., Wesselborg, Sebastian, Halayko, Andrew J., Klonisch, Thomas, Los, Marek Jan   +9 more
openaire   +3 more sources

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]

, 2017
International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu, Dorn, Gerald W, II, Flavell, Richard A, Han, Qingqing, Hunot, Stephane, Masters, Seth L, Naderer, Thomas, Seidi, Azadeh, Speir, Mary, Vince, James E, Vogrin, Adam   +10 more
core   +4 more sources

A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease

EMBO Journal, 2023
Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood.
Yu Cao, Jing Zheng, Huayun Wan, Yuqiu Sun, Song Fu, Shanshan Liu, Baiyu He, Gaihong Cai, Yang Cao, Huanwei Huang, Qi Li, Yan Ma, She Chen, Fengchao Wang, Hui Jiang   +14 more
semanticscholar   +1 more source

MicroRNA145 Targets BNIP3 and Suppresses Prostate Cancer Progression [PDF]

Cancer Research, 2010
Abstract The putative tumor suppressor miR145 is transcriptionally regulated by TP53 and is downregulated in many tumors; however, its role in prostate cancer is unknown. On the other hand, BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is overexpressed in various tumors, including prostate cancer, and may transcriptionally ...
Xueqin, Chen, Jing, Gong, Hao, Zeng, Ni, Chen, Rui, Huang, Ying, Huang, Ling, Nie, Miao, Xu, Juan, Xia, Fang, Zhao, Wentong, Meng, Qiao, Zhou   +11 more
openaire   +2 more sources

Deficit of female sex hormones desensitizes rat cardiac mitophagy

Chinese Journal of Physiology, 2021
Long-term deprivation of female sex hormones has been shown to mediate accumulation of damaged mitochondria in ventricular muscle leading to cardiovascular dysfunction.
Theerachat Kampaengsri, Marisa Ponpuak, Jonggonnee Wattanapermpool, Tepmanas Bupha-Intr   +3 more
doaj   +1 more source

Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. [PDF]

, 2016
Mitochondria abnormalities in skeletal muscle may contribute to frailty and sarcopenia, commonly present in patients with chronic kidney disease (CKD).
Billings, Frederic T, Bojanowski, Matthew T, Brown, Nancy J, Gamboa, Jorge L, Gilliam, Laura A, Himmelfarb, Jonathan, Ikizler, T Alp, Roberts, L Jackson, Roshanravan, Baback, Yu, Chang   +9 more
core   +1 more source

BNIP3 expression in follicular lymphoma

Histopathology, 2007
Aims:  To investigate the role of BNIP3, a 19‐kDa interacting protein of the Bcl‐2 family, alongside Bcl‐2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase‐3 (apoptotic markers) and Ki67 (proliferation marker).Methods and results:  Immunohistochemistry using monoclonal ...
Sington, J, Giatromanolaki, A, Campo, L, Turley, H, Pezzella, F, Gatter, K   +5 more
openaire   +2 more sources