Results 41 to 50 of about 21,955 (252)
Bnip3-mediated defects in oxidative phosphorylation promote mitophagy [PDF]
Autophagy, 2011 The Bcl-2 proteins are best known as regulators of the intrinsic mitochondrial pathway of apoptosis. However, recent studies have demonstrated that they can also regulate autophagy. For many years, autophagy was considered to be a nonselective process where the autophagosomes randomly sequestered contents in the cytosol to supply the cells with amino ...
Robert L, Thomas +2 more
openaire +2 more sources
Cell Death and Disease, 2023 Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal fibrosis remains unclear, and there is a lack of effective treatments,
Jialin Li +12 more
semanticscholar +1 more source
Autophagy and BNIP3 protein in tumorogenesis
Postępy Higieny i Medycyny Doświadczalnej, 2013 Autophagy is a process necessary for maintaining cell homeostasis in physiological conditions, as well as during certain stresses like nutrients or oxygen deprivation. Autophagy also plays an essential role in tumorigenesis. It prevents cell transformation, but on the other hand, autophagy enables existing cancer cells to adapt to harmful conditions ...
Ewelina, Swiderek, Leon, Strządała
openaire +2 more sources
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]
, 2014 Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne +3 more
core +2 more sources
Autophagy, 2023 The contribution of mitochondria to the metabolic function of hypoxic NP cells has been overlooked. We have shown that NP cells contain networked mitochondria and that mitochondrial translocation of BNIP3 mediates hypoxia-induced mitophagy.
Vedavathi Madhu +7 more
semanticscholar +1 more source
Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection [PDF]
, 2016 Mitochondria are the foremost producers of the cellular energy currency ATP. They are also a significant source of reactive oxygen species and an important buffer of intracellular calcium.
Bingol +66 more
core +2 more sources
BNIP3 promotes calcium and calpain-dependent cell death [PDF]
Life Sciences, 2015 Loss of cardiac muscle by programmed cell death contributes to the progression of ischemic heart disease. Hypoxia, metabolite waste buildup and energy depletion are components of ischemia which may initiate caspase dependent and independent cell death pathways.
Regina M, Graham +2 more
openaire +2 more sources
Cerebral Ischemic Preconditioning Aggravates Death of Oligodendrocytes
Biomolecules, 2022 Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning to preserve brain function, preconditioning is not yet considered ...
Teng Guan +7 more
doaj +1 more source
The effect of 4 weeks of continuous aerobic training with different volumes and starvation on the expression of some genes involved in liver mitophagy in healthy male Wistar rats [PDF]
ورزش و علوم زیست حرکتیIntroduction and Purpose: An increase in the number of defective mitochondria and their persistence can lead to apoptosis and necrosis of cells. Regular physical exercise along with time-restricted eating (TRE) can play an important role in improving ...
Hamzeh Bayani +3 more
doaj +1 more source
BNIP3 contributes to cisplatin‐induced apoptosis in ovarian cancer cells
FEBS Open Bio, 2020 BNIP3 is a proapoptotic protein that mediates apoptosis, necrosis and autophagy. However, the involvement of BNIP3 in cisplatin‐induced apoptosis in ovarian cancer is not clear.
Jinghui Jia +6 more
doaj +1 more source