BNIP3 promotes calcium and calpain-dependent cell death [PDF]
Life Sciences, 2015 Loss of cardiac muscle by programmed cell death contributes to the progression of ischemic heart disease. Hypoxia, metabolite waste buildup and energy depletion are components of ischemia which may initiate caspase dependent and independent cell death pathways.
Regina M, Graham +2 more
openaire +2 more sources
Challenges of drug resistance in the management of pancreatic cancer [PDF]
, 2010 The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada +119 more
core +1 more source
The effect of 4 weeks of continuous aerobic training with different volumes and starvation on the expression of some genes involved in liver mitophagy in healthy male Wistar rats [PDF]
ورزش و علوم زیست حرکتیIntroduction and Purpose: An increase in the number of defective mitochondria and their persistence can lead to apoptosis and necrosis of cells. Regular physical exercise along with time-restricted eating (TRE) can play an important role in improving ...
Hamzeh Bayani +3 more
doaj +1 more source
BNIP3 contributes to cisplatin‐induced apoptosis in ovarian cancer cells
FEBS Open Bio, 2020 BNIP3 is a proapoptotic protein that mediates apoptosis, necrosis and autophagy. However, the involvement of BNIP3 in cisplatin‐induced apoptosis in ovarian cancer is not clear.
Jinghui Jia +6 more
doaj +1 more source
Cerebral Ischemic Preconditioning Aggravates Death of Oligodendrocytes
Biomolecules, 2022 Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning to preserve brain function, preconditioning is not yet considered ...
Teng Guan +7 more
doaj +1 more source
Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]
, 2020 Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong +8 more
core
Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]
, 2014 The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara +9 more
core +3 more sources
Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover [PDF]
Cell Death & Differentiation, 2010 Bnip3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a mitochondrial BH3-only protein that contributes to cell death through activation of the mitochondrial pathway of apoptosis. Bnip3 is also known to induce autophagy, but the functional role of autophagy is unclear.
S, Rikka +6 more
openaire +2 more sources
BNIP3 Upregulation Characterizes Cancer Cell Subpopulation With Increased Fitness and Proliferation
Frontiers in Oncology, 2022 BNIP3 is a BH3-only protein with both pro-apoptotic and pro-survival roles depending on the cellular context. It remains unclear how BNIP3 RNA level dictates cell fate decisions of cancer cells.
Yanyan Zhu +9 more
doaj +1 more source
Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection [PDF]
, 2016 Mitochondria are the foremost producers of the cellular energy currency ATP. They are also a significant source of reactive oxygen species and an important buffer of intracellular calcium.
Bingol +66 more
core +2 more sources